Prediction of outcomes after radical prostatectomy in patients diagnosed with prostate cancer of biopsy Gleason score >/= 8 via contemporary multi(>/= 12)-core prostate biopsy.

摘要

Hong etal. report the results of radical prostatectomy in 151 men with Gleason score 8 to 10 prostate cancer on >12 core prostate biopsy from 2003 to 2009. In their study, the 5-year biochemical progression-free survival rate was only 41% overall, although the results were more favourable in the subset with organ-confined disease (5-year biochemical progression-free survival: 72.1%).Although these results would suggest that radical prostatectomy alone may be insufficient to cure the majority of men with high grade disease on biopsy, other studies have reported more favourable outcomes with radical prostatectomy in men with Gleason 8 to 10 disease and other high-risk features. For example, our group recently examined the results of radical prostatectomy in 175 men with D'Amico high-risk prostate cancer (PSA>20, clinical stage >T2c, or Gleason score 8 to 10) treated by a single surgeon [1].