STUDY OF PEANUT HUSK POWDER AS SUPERDISINTEGRANT IN THE FORMULATION OF FAST DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE

摘要

Fast dissolving tablets are considered as one of the rapidly moving products of novel drug delivery systems in the present pharmaceutical market. The development of new excipients for this technology is challenging task for pharmaceutical technologists. Disintegrants are one of the most important ingredients in the formulation of tablet dosage form. The aim of the present work was to test peanut husk powder, a natural material, as a disintegrant in the formulation of fast dissolving tablets of ondansetron hydrochloride. Tablet evaluation tests like hardness, friability, weight variation, disintegration and dissolution were performed for the prepared tablets. The obtained results were tabulated and they were found to be within the acceptable limits. Among all the formulations, formulation F6 containing peanut husk powder has shown the best disintegration property and based on the results it was found to be a superdisintegrant