Rhodium-Catalyzed Regioselective Ortho C-H Olefination of 2-Arylindoles via NH-Indole-Directed C-H Bond Cleavage

摘要

In the past decades, C-H oxidative olefination of indole at C-2, C-3, C-4 and C-7 positions was well addressed. We report here a rhodium-catalyzed NH-indole-directed ortho C-H bond olefination of 2-arylindoles. This cross-dehydrogenative-coupling proved to be broad in substrate scope, tolerating a variety of functional groups. The synthesis of 6H-isoindolo[2,1-]indoles via rhodium-catalyzed ortho C-H olefination and subsequent intramolecular aza-Michael reaction of 2-arylindoles was also demonstrated.