Association between Serum Testosterone and PSA Levels in Middle-Aged Healthy Men from the General Population

摘要

Introduction: The aim of the present study was to evaluate the association between serum testosterone and PSA levels in middle-aged healthy men from the general population. Materials and Methods: Based on 119 healthy men from the general population, total testosterone and PSA levels were measured. Demographic data regarding BMI, waist-to-hip ratio, smoking, and alcohol consumption were also collected. Men were classified into two groups according to testosterone levels; hypogonadal (testosterone < 12 nmol/l), and eugonadal (testosterone > 12 nmol/l). Results: The mean age of the subjects was 55 years (range 46-60 years). No significant correlation between serum testosterone and PSA levels was found (p = 0.60). PSA levels were similar when compared between hypogonadal and eugonadal men (1.4 jg/l vs. 1.4 ug/l, p = 0.90).When using a multivariate analysis model adjusted for the age of the subjects, BMI, waist-to-hip ratio, smoking, and alcohol consumption, a positive significant association between testosterone and PSA levels was found (P = 0.03, 95 % CI = 0.003-0.062, p = 0.03).