Integration of DNA Methylation Data and Gene Expression Data for Prostate Adenocarcinoma: A Proof of Concept

Singh Arpit; Rahman Razia; Hasija Yasha

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Integration of DNA Methylation Data and Gene Expression Data for Prostate Adenocarcinoma: A Proof of Concept

机译：用于前列腺腺癌的DNA甲基化数据和基因表达数据的整合：概念证明

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Background: Epigenetics is gaining rapid recognition as it accounts for heritable changes that do not involve changes in the coding sequence, but influences change in gene expressions. DNA methylation is the most extensively studied epigenetic mechanism and has been observed to play a significant role in gene regulation and silencing process.

机译：背景：表观遗传学正在获得快速识别，因为它占遗传性变化，不涉及编码序列的变化，而是影响基因表达的变化。 DNA甲基化是最广泛研究的表观遗传机制，并且已被观察到在基因调控和沉默过程中起着重要作用。

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来源
《Current Bioinformatics》 |2017年第5期|共8页
作者
Singh Arpit; Rahman Razia; Hasija Yasha;
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作者单位

Delhi Technol Univ Dept Biotechnol Main Bawana Rd Delhi 110042 India;

Delhi Technol Univ Dept Biotechnol Main Bawana Rd Delhi 110042 India;

Delhi Technol Univ Dept Biotechnol Main Bawana Rd Delhi 110042 India;

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原文格式 PDF
正文语种 eng
中图分类生物科学;
关键词
Epigenetics; DNA methylation; Prostate Adenocarcinoma (PRAD); The Cancer Genome Atlas (TCGA); differentially methylated regions; gene Expression;

机译：表观生物学;DNA甲基化;前列腺腺癌（PRAD）;癌症基因组图集（TCGA）;差异甲基化区域;基因表达;

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专利

1. Integration of DNA Methylation Data and Gene Expression Data for Prostate Adenocarcinoma: A Proof of Concept [J] . Singh Arpit, Rahman Razia, Hasija Yasha Current Bioinformatics . 2017,第5期

机译：用于前列腺腺癌的DNA甲基化数据和基因表达数据的整合：概念证明
2. A systems-level integrative framework for genome-wide DNA methylation and gene expression data identifies differential gene expression modules under epigenetic control [J] . Jiao YM, Widschwendter M, Teschendorff AE Bioinformatics . 2014,第16期

机译：用于全基因组DNA甲基化和基因表达数据的系统级整合框架，可确定在表观遗传控制下的差异基因表达模块
3. Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model. [J] . Morey-Kinney SR, Smiraglia DJ, James SR, Molecular cancer research: MCR . 2008,第8期

机译：在小鼠前列腺模型的转基因腺癌中，在前列腺癌进展过程中，DNA甲基转移酶表达，DNA高甲基化和DNA低甲基化的阶段特异性改变。
4. Normalization for cDNA microarray data of geneexpression profiles from the human prostate cancercell lines (PC3) by Pre-Processing Two-Color Data [C] . Dorina Bratfalean, Ramona Suharoschi, Crina Muresan, 19th European symposium on computer aided process engineering . 2009

机译：通过预处理双色数据对人前列腺癌细胞系（PC3）基因表达谱的cDNA微阵列数据进行归一化
5. Computational Methods for the Analysis of DNA Methylation and Gene Expression Data [D] . Lam, Larry Tao. 2016

机译：DNA甲基化和基因表达数据分析的计算方法
6. Identification of key DNA methylation-driven genes in prostate adenocarcinoma: an integrative analysis of TCGA methylation data [O] . Ning Xu, Yu-Peng Wu, Zhi-Bin Ke, 2019

机译：前列腺腺癌中关键DNA甲基化驱动基因的鉴定：TCGA甲基化数据的综合分析
7. Identification of key DNA methylation-driven genes in prostate adenocarcinoma: an integrative analysis of TCGA methylation data [O] . Ning Xu, Yu-Peng Wu, Zhi-Bin Ke, 2019

机译：前列腺腺癌中键DNA甲基化驱动基因的鉴定：TCGA甲基化数据的一致性分析

Integration of DNA Methylation Data and Gene Expression Data for Prostate Adenocarcinoma: A Proof of Concept

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