Lack of association between polymorphism -592A/C in the promoter region of IL10 gene and obsessive-compulsive disorder in Chinese Han population

摘要

Obsessive-compulsive disorder (OCD) isa debilitating and chronic neuropsychiatricdisorder with prevalence rates estimatedto be as high as 0.13% in MainlandChina (1), characterised by the presenceof symptoms such as intrusive, unwantedthoughts and ideas that cause an increasedamount of anxiety and intentional,repetitive behaviours (2). Evidencesuggests that immune deficiency may bedirectly implicated in the pathophysiologyof OCD, based on its symptomatic overlapwith depression and schizophrenia andbased on disturbances at the level of thehypothalamic-pituitary-adrenal axis (3,4).As an important immunoregulatorycytokine and Th2 cell cytokine, interleukin10 (IL10 ) is produced by lymphoid cellsand exerts its functions by the inhibition ofmacrophage/monocyte and T-cell lymphocytereplication and the secretion of inflammatorycytokines, such as IL12, tumournecrosis factor (TNF)-α and IL8. AlthoughIL10, located on chromosome 1q31–32,was previously reported to be linked tothe development of multiple diseases, suchas depressed mood (5) and schizophrenia(6) in genetic studies, the literatureregarding the association between IL10polymorphism and OCD remains poorlyunderstood.