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首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy
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Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy

机译：用针对实验性胶质母细胞瘤治疗的单链片段可变抗体武装1型单链病毒型，单链片段可变抗体。用于实验胶质母细胞瘤治疗

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摘要

Purpose: Glioblastoma (GBM) is resistant to standard of care. Immune checkpoints inhibitors (such as anti-PD-1 mAbs) efficiently restore antitumor T-cell activity. We engineered a new oncolytic herpes simplex virus (oHSV) expressing a single-chain antibody against PD-1 (scFvPD-1) to evaluate its efficacy in mouse models of GBM.
机译：目的：胶质母细胞瘤（GBM）耐受护理标准。 免疫检查点抑制剂（例如抗PD-1 mAb）有效地恢复抗肿瘤T细胞活性。 我们设计了一种新的肉瘤病毒（OHSV），表达针对PD-1（SCFVPD-1）的单链抗体，以评估其GBM小鼠模型中的功效。

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    Passaro Carmela; Alayo Quazim; De laura Isabella; McNulty John; Grauwet Korneel; Ito Hirotaka; Bhaskaran Vivek; Mineo Marco; Lawler Sean E.; Shah Khalid; Speranza Maria C.; Goins William; McLaughlin Eric; Fernandez Soledad; Reardon David A.; Freeman Gordon J.; Chiocca E. Antonio; Nakashima Hiroshi;

  • 作者单位

    Harvard Med Sch Dept Neurosurg Harvey W Cushing Neurooncol Labs HCNL Boston MA 02115 USA;

    Harvard Med Sch Dept Neurosurg Harvey W Cushing Neurooncol Labs HCNL Boston MA 02115 USA;

    Harvard Med Sch Dept Neurosurg Harvey W Cushing Neurooncol Labs HCNL Boston MA 02115 USA;

    Harvard Med Sch Dept Neurosurg Harvey W Cushing Neurooncol Labs HCNL Boston MA 02115 USA;

    Harvard Med Sch Dept Neurosurg Harvey W Cushing Neurooncol Labs HCNL Boston MA 02115 USA;

    Harvard Med Sch Dept Neurosurg Harvey W Cushing Neurooncol Labs HCNL Boston MA 02115 USA;

    Harvard Med Sch Dept Neurosurg Harvey W Cushing Neurooncol Labs HCNL Boston MA 02115 USA;

    Harvard Med Sch Dept Neurosurg Harvey W Cushing Neurooncol Labs HCNL Boston MA 02115 USA;

    Harvard Med Sch Dept Neurosurg Harvey W Cushing Neurooncol Labs HCNL Boston MA 02115 USA;

    Harvard Med Sch Dept Neurosurg Harvey W Cushing Neurooncol Labs HCNL Boston MA 02115 USA;

    Harvard Med Sch Dept Neurosurg Harvey W Cushing Neurooncol Labs HCNL Boston MA 02115 USA;

    Univ Pittsburgh Sch Med Dept Microbiol &

    Mol Genet Pittsburgh PA USA;

    Ohio State Univ Ctr Biostat Columbus OH 43210 USA;

    Ohio State Univ Ctr Biostat Columbus OH 43210 USA;

    Brigham &

    Womens Hosp 75 Francis St Boston MA 02115 USA;

    Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

    Harvard Med Sch Dept Neurosurg Harvey W Cushing Neurooncol Labs HCNL Boston MA 02115 USA;

    Harvard Med Sch Dept Neurosurg Harvey W Cushing Neurooncol Labs HCNL Boston MA 02115 USA;

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  • 正文语种 eng
  • 中图分类 肿瘤学;
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