Changes in plasma interleukin-8 and tumor necrosis factor-alpha levels during the early treatment period as a predictor of the response to sorafenib in patients with unresectable hepatocellular carcinoma

Iida-Ueno Ayako; Enomoto Masaru; Uchida-Kobayashi Sawako; Hagihara Atsushi; Teranishi Yuga; Fujii Hideki; Morikawa Hiroyasu; Murakami Yoshiki; Tamori Akihiro; Le Thi Thanh Thuy; Kawada Norifumi

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Changes in plasma interleukin-8 and tumor necrosis factor-alpha levels during the early treatment period as a predictor of the response to sorafenib in patients with unresectable hepatocellular carcinoma

机译：早期治疗期间血浆白细胞介素-8和肿瘤坏死因子-α水平的变化作为未切除的肝细胞癌患者索拉非尼的响应的预测因子

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Purpose This study aimed to identify a biomarker for predicting the response to sorafenib in patients with hepatocellular carcinoma (HCC).

机译：目的本研究旨在鉴定一种用于预测肝细胞癌（HCC）患者对索拉非尼的反应的生物标志物。

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来源
《Cancer chemotherapy and pharmacology.》 |2018年第5期|共8页
作者
Iida-Ueno Ayako; Enomoto Masaru; Uchida-Kobayashi Sawako; Hagihara Atsushi; Teranishi Yuga; Fujii Hideki; Morikawa Hiroyasu; Murakami Yoshiki; Tamori Akihiro; Le Thi Thanh Thuy; Kawada Norifumi;
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作者单位

Osaka City Univ Grad Sch Med Dept Hepatol Abeno Ku 1-4-3 Asahimachi Osaka 5458585 Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Abeno Ku 1-4-3 Asahimachi Osaka 5458585 Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Abeno Ku 1-4-3 Asahimachi Osaka 5458585 Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Abeno Ku 1-4-3 Asahimachi Osaka 5458585 Japan;

Osaka City Gen Hosp Dept Hepatol Osaka 5340021 Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Abeno Ku 1-4-3 Asahimachi Osaka 5458585 Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Abeno Ku 1-4-3 Asahimachi Osaka 5458585 Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Abeno Ku 1-4-3 Asahimachi Osaka 5458585 Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Abeno Ku 1-4-3 Asahimachi Osaka 5458585 Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Abeno Ku 1-4-3 Asahimachi Osaka 5458585 Japan;

Osaka City Univ Grad Sch Med Dept Hepatol Abeno Ku 1-4-3 Asahimachi Osaka 5458585 Japan;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Biomarker; HCC; IL-8; Prediction; Sorafenib; TNF-alpha;

机译：生物标志物;HCC;IL-8;预测;索拉非尼;TNF-alpha;

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专利

1. Changes in plasma interleukin-8 and tumor necrosis factor-alpha levels during the early treatment period as a predictor of the response to sorafenib in patients with unresectable hepatocellular carcinoma [J] . Iida-Ueno Ayako, Enomoto Masaru, Uchida-Kobayashi Sawako, Cancer chemotherapy and pharmacology. . 2018,第5期

机译：早期治疗期间血浆白细胞介素-8和肿瘤坏死因子-α水平的变化作为未切除的肝细胞癌患者索拉非尼的响应的预测因子
2. Plasma levels of tumor necrosis factor-alpha in adolescent idiopathic scoliosis patients serve as a predictor for the incidence of early postoperative cognitive dysfunction following orthopedic surgery [J] . Zheng Xu, Ma Zhengliang, Gu Xiaoping Experimental and therapeutic medicine . 2015,第4期

机译：青少年特发性脊柱侧凸患者血浆肿瘤坏死因子-α水平可作为骨科手术后早期术后认知功能障碍发生率的预测指标
3. The value of plasma levels of tumor necrosis factor-alpha and interleukin-6 in predicting the severity and prognosis in patients with congestive heart failure. [J] . Pan JP, Liu TY, Chiang SC, Journal of the Chinese Medical Association: JCMA . 2004,第5期

机译：血浆肿瘤坏死因子-α和白介素-6的水平在预测充血性心力衰竭患者的严重程度和预后中的价值。
4. Photoacoustic-ultrasonic imaging biomarkers for treatment-response assessment of sorafenib in a rat model of hepatocellular carcinoma [C] . Houra Taghavi, Nina Munoz, Mohamed Naser, IEEE International Ultrasonics Symposium . 2017

机译：光声-超声成像生物标记物用于索拉非尼在肝细胞癌大鼠模型中的治疗反应评估
5. Mechanisms of hepatocellular apoptosis induced by trovafloxacin-tumor necrosis factor-alpha interaction: An in vitro model of idiosyncratic drug-induced liver injury. [D] . Beggs, Kevin Michael. 2013

机译：曲伐沙星-肿瘤坏死因子-α相互作用诱导的肝细胞凋亡机制：特异药物诱导的肝损伤的体外模型。
6. Serum levels of soluble Fas soluble tumor necrosis factor-receptor II interleukin-2 receptor and interleukin-8 as early predictors of hepatocellular carcinoma in Egyptian patients with hepatitis C virus genotype-4 [O] . Abdel-Rahman N Zekri, Hanaa M Alam El-Din, Abeer A Bahnassy, 2010

机译：埃及丙型肝炎病毒基因4型患者血清可溶性Fas可溶性肿瘤坏死因子受体II白介素2受体和白介素8水平是肝细胞癌的早期预测指标
7. Serum levels of soluble Fas, soluble tumor necrosis factor-receptor II, interleukin-2 receptor and interleukin-8 as early predictors of hepatocellular carcinoma in Egyptian patients with hepatitis C virus genotype-4 [O] . Abdel-Rahman N Zekri, Hanaa El-Din, Abeer A Bahnassy, 2010

机译：埃及丙型肝炎病毒基因4型患者血清可溶性Fas，可溶性肿瘤坏死因子受体II，白介素2受体和白介素8水平是肝细胞癌的早期预测指标

Changes in plasma interleukin-8 and tumor necrosis factor-alpha levels during the early treatment period as a predictor of the response to sorafenib in patients with unresectable hepatocellular carcinoma

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