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Development and characterization of a camelid single‐domain antibody directed to human CD22 biomarker

机译：用于人CD22生物标志物的骆驼单结构域抗体的开发和表征

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Abstract > CD22 is a B‐cell‐specific trans‐membrane glycoprotein, which is found on the surface of the most B cells and modulates their function, survival, and apoptosis. Recently, targeting this cell surface biomarker in B‐cell malignancies and disorders has attracted a lot of attention. The variable domain of camelid single‐chain antibodies (VHH, nanobody) is a form of antibodies with novel properties including small size (15–17?kDa), thermal and chemical stability, high affinity and homology to human antibody sequences. In this study, a novel anti‐CD22‐specific VHH (Nb) has been developed and characterized by the screening of an immunized phage display library and its binding to CD22 + B cells is evaluated. Produced anti‐CD22 VHH had a single protein band about 17?kDa of molecular size in Western blotting and its binding affinity was approximately 9?×?10 ?9 ?M. Also, this product had high specificity and it was able to recognize the natural CD22 antigen in CD22+ cell lysate as well as on the cell surface (93%). This anti‐CD22 VHH with both high affinity and specificity recognizes CD22 antigen well and can be used in diagnosis and treatment of B cell disorders and malignancies. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> > cd22是一种B细胞特异性的跨膜糖蛋白，其在最多B细胞的表面上发现，并调节其功能，存活和凋亡。最近，针对B细胞恶性肿瘤和疾病的这种细胞表面生物标志物引起了很多关注。骆驼形单链抗体（VHH，纳米曲面）的可变结构域是一种具有新颖性质的抗体形式，包括小尺寸（15-17 kda），热和化学稳定性，对人抗体序列的高亲和力和同源性。在该研究中，已经开发了一种新的抗CD22特异性VHH（NB），并通过筛选免疫噬菌体显示文库，并评估与CD22 + </ sup> B细胞的结合。产生的抗CD22 VHH在蛋白质印迹中具有约17μm的单个蛋白质带，其分子尺寸，其结合亲和力约为9？×10 Δ9。此外，该产品具有很高的特异性，并且能够识别CD22 +细胞裂解物以及细胞表面（93％）中的天然CD22抗原。这种具有高亲和力和特异性的抗CD22 VHH均可均可均可用于诊断和治疗B细胞障碍和恶性肿瘤的诊断和治疗。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15016/'>《Biotechnology and Applied Biochemistry》</a> <b style="margin: 0 2px;">|</b><span>2018年第5期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Faraji Fatemeh&option=202" target="_blank" rel="nofollow">Faraji Fatemeh;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tajik Nader&option=202" target="_blank" rel="nofollow">Tajik Nader;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Behdani Mahdi&option=202" target="_blank" rel="nofollow">Behdani Mahdi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shokrgozar Mohammad Ali&option=202" target="_blank" rel="nofollow">Shokrgozar Mohammad Ali;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zarnani Amir Hassan&option=202" target="_blank" rel="nofollow">Zarnani Amir Hassan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shahhosseini Fatemeh&option=202" target="_blank" rel="nofollow">Shahhosseini Fatemeh;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Habibi‐Anbouhi Mahdi&option=202" target="_blank" rel="nofollow">Habibi‐Anbouhi Mahdi;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of ImmunologyIran University of Medical SciencesTehran Iran;</p> <p>Department of ImmunologyIran University of Medical SciencesTehran Iran;</p> <p>Biotechnology Research CenterPasteur Institute of IranTehran Iran;</p> <p>National Cell Bank of IranPasteur Institute of IranTehran Iran;</p> <p>Immunology Research Center (IRC)Iran University of Medical SciencesTehran Iran;</p> <p>National Cell Bank of IranPasteur Institute of IranTehran Iran;</p> <p>National Cell Bank of IranPasteur Institute of IranTehran Iran;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/180.html" title="生物工程学（生物技术）">生物工程学（生物技术）;</a><a href="https://www.zhangqiaokeyan.com/clc/177.html" title="生物化学">生物化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=CD22&option=203" rel="nofollow">CD22;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=camelid single‐domain antibody&option=203" rel="nofollow">camelid single‐domain antibody;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=VHH&option=203" rel="nofollow">VHH;</a> </p> <div class="translation"> 机译：CD22;骆驼醛单域抗体;VHH; 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