Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity A Randomized Clinical Trial

Baker Carl W.; Glassman Adam R.; Beaulieu Wesley T.; Antoszyk Andrew N.; Browning David J.; Chalam Kakarla V.; Grover Sandeep; Jampol Lee M.; Jhaveri Chirag D.; Melia Michele; Stockdale Cynthia R.; Martin Daniel F.; Sun Jennifer K.; Allen John Bradley; Punjabi Omar S.; Price Angela K.; Jones Taylor S.; Mahr Courtney; Herby Jenna T.; Murphy Brittany A.; McClain Ashley A.; Fredenberg Sherry L.; Fleming Christina J.; Lester Gina M.; Karow Angella S.; Breglio Erica; Grupp Autumn C.; Ennis Sarah A.; Bratcher Kayla A.; Watson Lynn; Bojaj Swann J.; McClain Donna; Finch Autumn K.; Dunlap Matt; McOwen Michael D.; Stobbe Shannon; Rowland Beverly O.; Jackson Lisa A.; Clark Loraine M.; Balasubramaniam Uma M.; Kimrey Kathryn; Ragin Teneisha A.; Held Susannah J.; Kuopus Jeff A.; Shore Carol A.; Wykoff Charles C.; Kim Rosa Y.; Shah Ankoor R.; Schefler Amy C.; Wong Tien P.; Fish Richard H.; Chen Eric; Major James C.; Benz Matthew S.; Brown David M.; Hutson Amy; Twining Garret L.; Supapo Stacy M.; Karani Sadia Y.; Landaverde Nubia; Berry Meredith; Estes Maura A.; Bocanegra Melisa M.; Epp Lauren; Williamson Kimberly; Carranza Jolene; Park Daniel; Foerster Danee; Chancey Ashley E.; Vo-Le Bylinda; Rodriguez Diana; Dives Brenda; Sneed Veronica A.; Royse Tressa; Yee Rebecca; Koger-Grifaldo Heather; Almanza Belinda A.; Quellar Elizabeth; Salinas Luis R.; Richter Beau A.; Stoever Cary A.; Dodel Tamara L.; Kegley Eric N.; James Miranda F.; Gupta Shailesh K.; Hamdani Ghulam Shabbir; Cowart Ashley; Sambhav Kumar; Li Wenhua; Mynampati Bharani Krishna; Smith Jazzmin N.; White Cheryl L.; Zhou Zimei; Hart Sherrie D.; Freeman Nicholas; Tilford Ron H.; Caldwell Tracey M.; Baker Jil D.; Martin Tracey R.; Orr Margaret J.; Lambert Lynnette F.; Sharp Mary J.; Kettler Samantha; Williams Tana R.; Camp Alecia B.; Sedberry Kylie S.; Chexal Saradha; Berger Brian B.; Wilson Daniela Mariel; Gunderson Ivana; Hosein Kimberly; Tracy Jenny J.; Moore Tori; Renfroe Cori; Seidu Tina A.; Reid Ryan M.; Nguyen Brandon; Bravenec Chelsey A.; Luong Bianca; Harara Abla M.; Palacios Angela N.; Corak Boris; Stovall Christopher C.; Rocha Erik; Ren Yong; Pieramici Dante J.; Dhoot Dilsher; Castellarin Alessandro A.; Do Timothy; Esau Sara; Hong Gina; Morasse Erica D.; Giust Jack; McDermott John; Card Kevin; Hanna Michelle S.; Fishbein Sarah; Avery Kelly; Smith Jerry; Walker Aimee; Ruvalcaba Nitce L.; Fullenkamp Austin; Spaeth Susan; Giust Matthew; Shook Aimee H.; Murtha Timothy J.; Schlossman Deborah K.; Silva Paolo S.; Arrigg Paul G.; Sharuk George S.; Shah Sabera T.; Miranda Linette; Kieser Troy; Degan Emily; Kwak Hanna; Stockman Margaret E.; Cavallerano Jerry D.; Papaconstantinou Steve L.; Tran Katie V.; Bestourous Leila; Krigman Michael N.; Carli William; Kirby Rita K.; Glynn Shireen; Weimann Elizabeth S.; Madigan Kylie M.; Palitsch Kate A.; Bertoni Bruno; Cavicchi Robert W.; Fox Gregory M.; Singh Ravi S. J.; Batlle Ivan R.; Suiter Beatty G.; Cooper Blake A.; Ainley Lexie R.; Batlle Karla A.; VandeVelde Amber R.; Hall Liz; Bruce Kiersten; Wyrick Holly; Pippin Katherine; Perkins Samantha; Yeager Frank T.; Shah Sandeep N.; Phelps Brian S.; Harmon Natasha; Longstreth Stuart; Babaria Romesh; Rodriguez Jeannette; Shubert Brooklyn; Baker Taylor; Cox Jessica; Meiwes Kellie; Viruet-Nieves Mayra; Rosenthal William N.; Lamaster Sarah N.; Delich Mary C.; Kaminski Michelle M.; Varner R. Scott; Googe Joseph M.; Anderson Nicholas G.; Shuler R. 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首页> 外文期刊>JAMA: the Journal of the American Medical Association >Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity A Randomized Clinical Trial

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Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity A Randomized Clinical Trial

机译：初始管理与AFLIBERCEPT的效果VS激光光凝患者对患有糖尿病性黄斑水肿患者视力丧失的观察，涉及疗效的患者和良好的视力随机临床试验

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摘要

IMPORTANCE Intravitreous injections of antivascular endothelial growth factor agents are effective for treating diabetic macular edema (DME) involving the center of the macula (center-involved DME [CI-DME]) with visual acuity impairment (20/32 orworse). The best approach to treating patients with CI-DME and good visual acuity (20/25 or better) is unknown.

机译：重要的静脉内注射抗病毒内皮生长因子剂是治疗涉及黄斑（中央DME [CI-DME]）的糖尿病黄斑水肿（DME）的有效视力障碍（20/32 orworse）。治疗CI-DME患者和良好的视力（20/25或更高）治疗患者的最佳方法是未知的。

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《JAMA: the Journal of the American Medical Association》 |2019年第19期|共15页
作者
Baker Carl W.; Glassman Adam R.; Beaulieu Wesley T.; Antoszyk Andrew N.; Browning David J.; Chalam Kakarla V.; Grover Sandeep; Jampol Lee M.; Jhaveri Chirag D.; Melia Michele; Stockdale Cynthia R.; Martin Daniel F.; Sun Jennifer K.; Allen John Bradley; Punjabi Omar S.; Price Angela K.; Jones Taylor S.; Mahr Courtney; Herby Jenna T.; Murphy Brittany A.; McClain Ashley A.; Fredenberg Sherry L.; Fleming Christina J.; Lester Gina M.; Karow Angella S.; Breglio Erica; Grupp Autumn C.; Ennis Sarah A.; Bratcher Kayla A.; Watson Lynn; Bojaj Swann J.; McClain Donna; Finch Autumn K.; Dunlap Matt; McOwen Michael D.; Stobbe Shannon; Rowland Beverly O.; Jackson Lisa A.; Clark Loraine M.; Balasubramaniam Uma M.; Kimrey Kathryn; Ragin Teneisha A.; Held Susannah J.; Kuopus Jeff A.; Shore Carol A.; Wykoff Charles C.; Kim Rosa Y.; Shah Ankoor R.; Schefler Amy C.; Wong Tien P.; Fish Richard H.; Chen Eric; Major James C.; Benz Matthew S.; Brown David M.; Hutson Amy; Twining Garret L.; Supapo Stacy M.; Karani Sadia Y.; Landaverde Nubia; Berry Meredith; Estes Maura A.; Bocanegra Melisa M.; Epp Lauren; Williamson Kimberly; Carranza Jolene; Park Daniel; Foerster Danee; Chancey Ashley E.; Vo-Le Bylinda; Rodriguez Diana; Dives Brenda; Sneed Veronica A.; Royse Tressa; Yee Rebecca; Koger-Grifaldo Heather; Almanza Belinda A.; Quellar Elizabeth; Salinas Luis R.; Richter Beau A.; Stoever Cary A.; Dodel Tamara L.; Kegley Eric N.; James Miranda F.; Gupta Shailesh K.; Hamdani Ghulam Shabbir; Cowart Ashley; Sambhav Kumar; Li Wenhua; Mynampati Bharani Krishna; Smith Jazzmin N.; White Cheryl L.; Zhou Zimei; Hart Sherrie D.; Freeman Nicholas; Tilford Ron H.; Caldwell Tracey M.; Baker Jil D.; Martin Tracey R.; Orr Margaret J.; Lambert Lynnette F.; Sharp Mary J.; Kettler Samantha; Williams Tana R.; Camp Alecia B.; Sedberry Kylie S.; Chexal Saradha; Berger Brian B.; Wilson Daniela Mariel; Gunderson Ivana; Hosein Kimberly; Tracy Jenny J.; Moore Tori; Renfroe Cori; Seidu Tina A.; Reid Ryan M.; Nguyen Brandon; Bravenec Chelsey A.; Luong Bianca; Harara Abla M.; Palacios Angela N.; Corak Boris; Stovall Christopher C.; Rocha Erik; Ren Yong; Pieramici Dante J.; Dhoot Dilsher; Castellarin Alessandro A.; Do Timothy; Esau Sara; Hong Gina; Morasse Erica D.; Giust Jack; McDermott John; Card Kevin; Hanna Michelle S.; Fishbein Sarah; Avery Kelly; Smith Jerry; Walker Aimee; Ruvalcaba Nitce L.; Fullenkamp Austin; Spaeth Susan; Giust Matthew; Shook Aimee H.; Murtha Timothy J.; Schlossman Deborah K.; Silva Paolo S.; Arrigg Paul G.; Sharuk George S.; Shah Sabera T.; Miranda Linette; Kieser Troy; Degan Emily; Kwak Hanna; Stockman Margaret E.; Cavallerano Jerry D.; Papaconstantinou Steve L.; Tran Katie V.; Bestourous Leila; Krigman Michael N.; Carli William; Kirby Rita K.; Glynn Shireen; Weimann Elizabeth S.; Madigan Kylie M.; Palitsch Kate A.; Bertoni Bruno; Cavicchi Robert W.; Fox Gregory M.; Singh Ravi S. J.; Batlle Ivan R.; Suiter Beatty G.; Cooper Blake A.; Ainley Lexie R.; Batlle Karla A.; VandeVelde Amber R.; Hall Liz; Bruce Kiersten; Wyrick Holly; Pippin Katherine; Perkins Samantha; Yeager Frank T.; Shah Sandeep N.; Phelps Brian S.; Harmon Natasha; Longstreth Stuart; Babaria Romesh; Rodriguez Jeannette; Shubert Brooklyn; Baker Taylor; Cox Jessica; Meiwes Kellie; Viruet-Nieves Mayra; Rosenthal William N.; Lamaster Sarah N.; Delich Mary C.; Kaminski Michelle M.; Varner R. Scott; Googe Joseph M.; Anderson Nicholas G.; Shuler R. Keith; Oliver Kristina; Lovelady Lisa; Morris Steve; Coppola Patricia; Schulz Kathy L.; Rauen Julie; Walsh Justin; Whetstone Jerry K.; Lince Raul E.; Oelrich Sarah M.; Blinder Kevin J.; Krummenacher Thomas K.; Smith Bradley T.; Nobel Ginny S.; Hoehn Erika A.; Weeks Rhonda F.; Stuart Maria A.; Boyd Lynda K.; Pepple Kelly E.; Reardon Diana; Pulliam Brook G.; Guevara Stephanie L.; Gabel Dana L.; Guevara George; Wehmeier Jarrod; Wright Timothy L.; Schremp Steve A.; Peters Mark A.; Ma Colin; Patel Apurva K.; Tlucek Paul S.; Lee Michael S.; Puckett Brian S.; Ho Stephanie L.; Smith Pualani; Hobbs Stephen; Milliron Amanda C.; Charpentier Margaret E.; Kopfer Marcia; Connaughton Michele; Logan Joe; Hoerner Christine; Cohen Joshua; Wirthlin Robert S.; Guglielmo Eric S.; Cheek Andrew G.; Dittman Eileen A.; Waidelich Dylan C.; Erstad Jillian N.; Skea Brian G.; Atwood Lori L.; Garza Cristofer J.; Owens Christina; Oakes Ashley Nicole; Stone Adeline M.; Leder Henry A.; Starr JoAnn; Belz Jennifer L.; Robinson Twyla J.; Singletary Pamela V.; Coffey Teresa; Thompson Amy; Simpson Perel M.; Davis Ashley; Orr Peggy R.; Simmons Jennifer L.; Sandler Dallas R.; McCalla Alesia K.; Sotirakos Peter; Metzger AshleyM.; Cain Terri; Weng Christina Y.; Coffee Robert E.; Carvounis Petros Euthymiou; Joshi Annika S.; Hemati Pejman; Schuetzle Karri; Blacutt Wendy; Olfson Margaret M.; Leger April; Barnett Dana B.; Morales Joseph F.; Harless Ashley M.; Novak Carolee K.; Ware Alisha; Steele Thomas; Ellingwood Nicole; White Lorraine; Harris Charlotte; Edwards Paul Andrew; Gao Hua; Kumar Nitin; Desai Uday; Hessburg Thomas; Hall Julianne; Oude-Reimerink Dinah S.; Ventimiglia Katie M.; Mazurek Melina; Monk Mary K.; Murphy Janet; Massu Nicole M.; Troszak Tracy A.; Staffne Jessica L.; Humenny Jennifer A.; Grybas John; Brouhard Kris; Shaheen Jenny; Ashley Derick S.; Stern Bradley A.; Rusinek Brian A.; Burley David; Husaynu Dawn; Allis Megan; Ghuman A. Thomas; Walker Joseph P.; Wing Glenn; Sharma Ashish G.; Raskauskas Paul A.; Knips Eileen; Peters Crystal Y.; Ryan Cheryl; Greenhoe Laura; Torres Natalie N.; Kiesel Cheryl; Leslie Anita H.; Dyshanowitz Danielle; Kiesel Raymond K.; Friedman Scott M.; Moinfar Nader; Rehling Shannon M.; Dawson Katrina L.; Fagan Damanda F.; Williamson Kimberly A.; Walters Paige N.; Andrews Jacqueline; Williams Shana E.; Bobbitt Brenda J.; McKinney Allen; Carlton Steve; Schadlu Ramin; Schadlu Anita Prasad; Fox Erin; Smith Brigid; Ford Justin F.; Carpenter Meaghan L.; Butler Lindsey; Cook Ronald Sean; Tonche Juan; Hylands Jacob Michael; Binder Travis; Brar Vikram S.; Trent Angela J.; Sok Meagan D.; Halloway Dianne E.; Newton Joseph N.; Chisholm James S.; Bennett David; Chang Margaret A.; Tsai Tony; Wendel Robert T.; Pearlman Joel A.; Reed John Brian; Kinnison Michael D.; Wong Kimberlee S.; Magee Maya; Zabel Nyla; Rizo Annaliza; Bair Eric; Gonzalez Marta; Singh Harinderjit; Ortiz Siobhan O.; Farooq Amina; Roberts Courtney N.; Parsons Brook; Foster Lindsay Allison; Bailey Thomas; Gardner Jared C.; Woodward Michele; Ivey Ken; Dessouki Amr; Chow Clement; Barra Joel M.; Ly Hoa K.; Nguyen Thanh T.; Dang Hienmy; To Kelly; Rocha Pamela; Dao Tran; Kelley Tim; Gonzalez Victor Hugo; Diaz-Rohena Roberto; Patel Nehal R.; Santiago Juan G.; Adyanthaya Rohit; Salinas Yesenia; Anaya Deyla; Salinas Kethsaly J.; Villanueva Lissete O.; Garcia Dina; Alvarez Crystal A.; Pina Ana L.; Ibarra Amber B.; Garza Angelina; Reyes David A.; Arredondo Janette; Miranda Karina; Cantu Monica R.; Garza Maricela; Flores Rebecca R.; Rodriguez Rachel; Moreno Jennifer; Cabrera Isaac; Gonzalez Tiffany; Diaz Yvonne; Villegas Christina; Leal Ashley; Jasso Hector; Alonso Samuel; Aguero Lazaro; Garza Santos; Montemayor Monique; Desai Shilpa; Chace Richard; Vasquez Samantha; Kallay Sunny; Wood Jillian; Dolbec Nicole; Stevens Kirsten; Surette Janea; Barkmeier Andrew J.; Rubin Heidi Suzanne; Currie Gillian A.; Baker Betsy A.; Sultze Jane L.; Overend Joan T.; Morgan Jessica Ann; Burrington Jean M.; Tesmer Jaime L.; Einck Stephanie L.; Goddard Shannon; Lewison Denise M.; Mein Calvin E.; Chica Moises A.; Kirschbaum Lita; Moore Tori R.; Martinez Vanessa D.; Baker Jaynee; Castillo Elaine; Marquez Clarissa M.; Wienecke Christopher Sean; Nakoski Brenda; Solomon Sharon D.; Levin Lisa K.; Donohue Deborah; Frey Mary; Murray Keisha; Emmert David; Distle Russ; Rhoton Nick; McDonald Jacquelyn; Belz Joe; Herring Charles; Cain Dennis; Moore Bob; Graul Janis; Shienbaum Gary; Lara Wilfredo C.; Gonzalez Marco A.; Garcia Pamela; Lara David; Aguero Maria; Rodriguez Jaziel; Olsen Karl R.; Knickelbein Jared E.; Vyas Avni Patel; Bergren Robert L.; Doft Bernard H.; Rath Pamela P.; Merlotti Lori A.; Chamberlin Jennifer L.; Kelly Mary E.; Mechling Holly M.; Forish Missy A.; Walter Julie; Schultz Christina M.; Rigoni Grace A.; Yeckel Kimberly A.; Bennett Veronica L.; Stepansky Lois; McBroom Keith D.; Steinberg David; Foreman Courtney L.; Ostroska Phyllis P.; Diperna Dawn; Rosberger Daniel F.; Wangmo Phuntsho; Bendarkawi Sarah; Groeschel Sandra; Yaseen Mohammed; Acevedo Sandra; Gyaltshen Sonam; Santora Robert; Gomez Yenelda M.; Kwun Robert C.; Howard James G.; Winward Kirk E.; Knudsen Victoria L.; Swartz Mano; Marshall Cassie; Riley Michelle; Ma Shauna; Gurley Bobbie; Taylor Gena; Taylor Teresa; Walsh Daniel; Winward Jason G.; Holt Michelle; Walsh Adam; King-Brown Terri; Suner Ivan J.; Peden Marc C.; Hammer Mark E.; Traynom Janet R.; DenBoer Rochelle; Ramsey Susan; Vargo Heidi; Malzahn Anita Kim; Christoforidis John B.; Bulau Sue A.; Brickman-Kelleher Jill; Kowren Jennifer; Fryer Patricia H.; Gallego Danielle N.; Haymore Dennis; Breazeale Richard I.; DeCroos Francis C.; Shah Rohan J.; Ghodasra Devon; McBee Steve W.; McDonald Elizabeth Lisa; Corbitt Kaitlin J.; Duncan Courtney; Menefee Kate; Moore Morgan C.; Jones Nicholas E.; Melendrez Roger P.; Woods David; Lyon Alice T.; Mirza Rukhsana G.; Krug Amanda M.; Santillanes Crystal; Davies Evan C.; Johnson Julie; Seddon Nicole M.; Ramirez Carmen; Brooks Natalia L.; Galvan Alma; Skelly Marriner L.; Moore Cason; Degillio Andrea R.; Truhan Alan; Simjanoski Evica; Barragan Maritza; Glazer Louis C.; Garber Frank W.; Zheutlin Jeffrey D.; Listerman Angela D.; Feehan Christine E.; Cruz Heather L.; Kuitula Donald E.; Weatherbee Sue; Gottlieb Justin; Blodi Barbara A.; Ip Michael S.; Dietzman Kristine A.; Smith Christopher M.; Adler Angela M.; Reed Sandie L.; Peterson John C.; Krolnik Denise A.; Flaxel Christina J.; Bailey Steven T.; Campbell J. Peter; Hwang Thomas S.; Schain Mitchell; Hanel Shelley A.; Lundquist Ann D.; Maykoski Jennifer K.; Nolte Susan K.; Howell Chris S.; Hui Jocelyn T.; Steinkamp Peter N.; Barth Jordan; Ukachukwu Chiedozie; Pickell Scott R.; Ryan Dawn M.; Hall Edward F.; Guillet Ernest G.; Connolly Brian P.; Rose Steven J.; Yagoda Margaret M.; Doran Mary Jo; Burgess Mindy; Reynard Ann; Whelehan Margaret; Nelson Ryan W.; Territo Joe; Miller David G.; Novak Michael A.; Schartman Jerome P.; Rao Llewelyn J.; Singerman Lawrence J.; Coney Joseph M.; Rath Susan C.; Smith Veronica A.; Rykena Cecelia; Tanner Vivian; Ilc Mary A.; Amonett William B.; McNamara Elizabeth; DuBois John C.; Greanoff Gregg A.; Garg Seema; Houghton Odette M.; Ulrich Jan Niklas; DuBose Elizabeth L.; Bhansali Kanika A.; Barnhart Cassandra J.; Benton Sarah E.; Cantrell Debra; Sharpe Houston P.; Esquejo Rona Lyn; Trichonas Georgios; Kim Yu Hyon; Huang Suber S.; Ahmad Baseer U.; Sedlacek Hillary M.; Riedel Tatiana M.; Ferguson Lisa P.; Nitzsche Trina M.; Allchin Peggy; Sholtis Kelly A.; Carlton Kathy; Clow Claudia; Pankhurst Geoffrey; Harrod Mark A.; Hrvatin Stacie A.; Baum-Rawraway Irit; Scott Michael H.; Walsh Shannon R.; Tebon Brenda L.; Moyle Marcia J.; Stone Thomas W.; Kitchens John W.; Isernhagen Rick D.; Purkiss Todd J.; Shirkey Belinda L.; VanHoose Brenda; Bicknell Lisa; Van Arsdall Jeanne; Brown Chris; Noel Bryan; Slade Edward A.; Buck Michelle; Gasperini Julie L.; Frank Charisse M.; Mujica Angie Y.; Becerra Jonathan; Rodriguez Irasema; Delgado Steve; Meleth Annal Dhanu; Kooragayala Lakshmana Murthy; Lewis Chenavia; Sewell Shakirah J.; Jackson Minuette S.; Sircar Samantha; Thompson Kenneth; Goff Adam; Sheth Veeral S.; Jager Rama D.; Zwicky Karen; Keating Erin B.; Hammond Kristine; Bhagat Davis; Kim Benjamin J.; VanderBeek Brian L.; Drossner Sheri; DuPont Joan C.; Farazdaghi Armin; Chen Judy; Devine Cheryl; Morales Sara; Serpentine Beth; Berger Jim M.; OKeefe John Stewart; Astruc Juan A.; Schwent Bryan J.; Tabassian Ali R.; Rosen Suzette A.; Tutka Melissa A.; Driver Robin M.; Gomer Brian; Michaels Jeffrey; Arndt Natalie J.; Maziarz John J.; Rosenberg Kevin I.; Brown Jamin S.; Hampton G. Robert; Sienkiewycz Laurie J.; Hall Christine S.; Gabris Victoria L.; Manley Michelle L.; Bellows Brandi M.; Kwasniewski Lynn M.; Spuches Lisa; DeForge Teresa M.; DeSantis Stefanie R.; Hay Peter B.; Barker Jeffrey P.; Robarge Nicole E.; Miller Abigail; Labriola Leanne T.; Tsipursky Michael S.; Gore Tina M.; Bradley Paula; Charles Lauryn E.; Almasov Alexandra Y.; Neef Ashley T.; Myers Lindsey H.; Williams John; Fitzgerald Amber; Nielsen Daniel A.; Knoke Sharon; Bruce Mary B.; Dupureur Zach; Funk Katherine E.; Brown Joseph F.; Navajas Eduardo Vitor; Maberley David A. L.; Kirker Andrew William; Wiens Theresa; Jovanovic Mira; Kuzmanovic Aleksandra; Chang Angela; Elvena Garnet Louise; Grant Kelly; Godfrey Anne-Marie; Ysasaga J. Edward; Rush Ryan B.; Dalrymple Kasey L.; Villegas Ashley N.; Ysasaga Stella D.; Hawkins Johnathan R.; Ysasaga Ben; Edwards Albert O.; Hunter Allan A. III; Wallace Jonathan; Lebien Ryan G.; Worthington Skyler S.; Bale Elizabeth A. 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III; Jaffe Glenn J.; Lujan Brandon; MacCumber Mathew; Marcus Dennis M.; Maturi Raj K.; Aiello Lloyd Paul; Bhavsar Abdhish; Brucker Alexander J.; Danis Ronald P.; Davis Matthew D.; Elman Michael J.; Everett Donald F.; Fish Joan; Friedman Scott; Googe Joseph Jr.; Gross Jeffrey G.; Holcomb Diana M.; Kim Judy E.; Lauer Andreas; McClain Ashley; Perez Brandi J.; Schron Eleanor; Scott Ingrid U.; Abrams Gary; Barnbaum Deborah R.; Flynn Harry; Rudser Kyle D.; Sternberg Paul; Bhargava Sangeeta; Weinstock Ruth S.; Wisniewski Stephen; Connett John; Wilkinson Charles P.; Mora Adiel; Foster Lucia; Young Ellen; Harrington Chris; Jaffe Glenn; Winter Trina; Inman Kelly; Heydary Cindy; Myers Justin; Shields Kelly; Busian Dee; Blodi Barbara; Domalpally Amitha; Reimers James L.; Vargo Pamela; Myers Dawn; Lawrence Daniel; Allan James; Harris Ashley; Corkery Ellie; Dohm Kristi L.; Lang Kristine; Shaw Ruth; Watson Sheila; Benz Wendy K.;
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中图分类医药、卫生;
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专利

1. Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity A Randomized Clinical Trial [J] . Baker Carl W., Glassman Adam R., Beaulieu Wesley T., JAMA: the Journal of the American Medical Association . 2019,第19期

机译：初始管理与AFLIBERCEPT的效果VS激光光凝患者对患有糖尿病性黄斑水肿患者视力丧失的观察，涉及疗效的患者和良好的视力随机临床试验
2. Assessment of the DRCR Retina Network Approach to Management With Initial Observation for Eyes With Center-Involved Diabetic Macular Edema and Good Visual Acuity A Secondary Analysis of a Randomized Clinical Trial [J] . Glassman Adam R., Baker Carl W., Beaulieu Wesley T., JAMA ophthalmology . 2020,第4期

机译：初步观察中枢神经糖尿病黄斑水肿和良好的视力评估对管理的初步观察，对随机临床试验的次要视力进行评估
3. New Findings From Diabetic Retinopathy Clinical Research Retina Network Protocol V Confirm a Role for Focal Laser Photocoagulation or Observation for Eyes With Center-Involved Diabetic Macular Edema and Good Visual Acuity: New Is Not Always Best [J] . Peto Tunde, Chakravarthy Usha JAMA ophthalmology . 2019,第7期

机译：糖尿病视网膜病变临床研究的新发现视网膜网络协议v确认了局灶性激光光凝或观察中枢神经糖尿病黄斑水肿和良好的视力的作用：新的并不总是最好的
4. Prediction of visual acuity loss and indications for laser treatment in patients with diabetic macular edema using the Heidelberg Retina Tomograph. [D] . O'Neal, Dennis A. 2007

机译：使用海德堡视网膜断层扫描仪预测糖尿病性黄斑水肿患者的视力下降和激光治疗的适应症。
5. Randomised clinical trial evaluating best-corrected visual acuity and central macular thickness after 532-nm subthreshold laser grid photocoagulation treatment in diabetic macular oedema [O] . W Pei-pei, H Shi-zhou, T Zhen, 2015

机译：评估532 nm亚阈值激光格栅光凝治疗糖尿病性黄斑水肿后最佳矫正视力和中央黄斑中心厚度的随机临床试验
6. Intravitreal Aflibercept Injection in Eyes With Substantial Vision Loss After Laser Photocoagulation for Diabetic Macular Edema [O] . Charles C. Wykoff, Dennis M. Marcus, Edoardo Midena, 2017

机译：玻璃体内AfliBercept注射在激光光凝后患有大量视力丧失的眼睛，用于糖尿病黄斑水肿

Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity A Randomized Clinical Trial

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