Lipid parameters and cardiovascular events in patients taking statins - Reply

摘要

Drs Martin and Jones agree with us that individuals reaching their LDL-C target but not their non-HDL-C target are at increased cardiovascular risk, whereas the opposite was not the case. They requested 2 additional analyses. People reaching the LDL-C target of 70 mg/dL but not the non-HDL-C target of 100 mg/dL were not at increased cardiovascular risk (HR, 1.05; 95% CI, 0.88-1.26) compared with those reaching both targets. The same is true for those reaching the non-HDL-C but not the LDL-C target (HR, 0.93; 95% CI, 0.82-1.05). A similar analysis using the LDL-C target of 100 mg/dL and the apoB target of 80 mg/ dL, as suggested by Contois et al, yielded slightly different results. Those reaching the LDL-C but not the apoB target were at increased cardiovascular risk (HR, 1.13;95% CI, 1.05-1.22). People reaching the apoB but not the LDL-C target had a slightly higher HR of 1.18 (95% CI, 0.96-1.45), but this estimate did not reach statistical significance due to a low number of events.