Senescence marker protein-30 (SMP30) and its gerontological significance

摘要

We have isolated and characterized a novel protein designated as senescence marker protein-30 (SMP30). The amount of SMP30 decreases in an androgen-independent manner with increasing age in the rat liver. SMP30 turned out to be identical to a calcium-binding protein called regucalcin. In this review; we give an overview of the structure, expression and possible physiological role(s) of SMP30. We also discuss the hypothetical role of SMP30 in aging and calcium homeostasis. [References: 20]