Genetic Predisposition to Symptomatic Lumbar Disk Herniation in Pediatric and Young Adult Patients

Theodore Nicholas; Ahmed Ali Karim; Fulton Travis; Mousses Spyro; Yoo Christopher; Goodwin Courtney Rory; Danielson Jill; Sciubba Daniel M.; Giers Morgan B.; Kalani Mohammad Yashar S.

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Genetic Predisposition to Symptomatic Lumbar Disk Herniation in Pediatric and Young Adult Patients

机译：儿科和年轻成人患者症状腰椎肿瘤疝的遗传易感性

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Study Design. Case-control whole-genome sequencing analysis of a highly select, young cohort with symptomatic lumbar disk herniation (LDH) compared with the standard variation in a large reference population.

机译：学习规划。案例控制全基因组测序分析高度选择，患有症状腰椎盘疝（LDH）的高度选择，与大参考群体的标准变异相比。

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来源
《Spine》 |2019年第11期|共10页
作者
Theodore Nicholas; Ahmed Ali Karim; Fulton Travis; Mousses Spyro; Yoo Christopher; Goodwin Courtney Rory; Danielson Jill; Sciubba Daniel M.; Giers Morgan B.; Kalani Mohammad Yashar S.;
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作者单位

St Josephs Hosp Barrow Neurol Inst Dept Neurosurg Phoenix AZ 85013 USA;

Johns Hopkins Univ Sch Med Dept Neurosurg Baltimore MD 21205 USA;

St Josephs Hosp Barrow Neurol Inst Dept Neurosurg Phoenix AZ 85013 USA;

Syst Imaginat Inc Phoenix AZ USA;

Syst Imaginat Inc Phoenix AZ USA;

Johns Hopkins Univ Sch Med Dept Neurosurg Baltimore MD 21205 USA;

St Josephs Hosp Barrow Neurol Inst Dept Neurosurg Phoenix AZ 85013 USA;

Johns Hopkins Univ Sch Med Dept Neurosurg Baltimore MD 21205 USA;

St Josephs Hosp Barrow Neurol Inst Dept Neurosurg Phoenix AZ 85013 USA;

St Josephs Hosp Barrow Neurol Inst Dept Neurosurg Phoenix AZ 85013 USA;

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原文格式 PDF
正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
aggrecan; cartilaginous end plate; collagen; collagen-encoding genes; genome-wide association study; intervertebral disk disease; lumbar disk herniation; missense mutation; next-generation sequencing; single-nucleotide polymorphism; variants;

机译：聚乙烯;软骨末端板;胶原蛋白;编码基因;基因组关联研究;椎间盘疾病;腰椎椎间盘突出;畸变突变;下一代测序;单核苷酸多态性;变体;

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1. Genetic Predisposition to Symptomatic Lumbar Disk Herniation in Pediatric and Young Adult Patients [J] . Theodore Nicholas, Ahmed Ali Karim, Fulton Travis, Spine . 2019,第11期

机译：儿科和年轻成人患者症状腰椎肿瘤疝的遗传易感性
2. Symptomatic magnetic resonance imaging-confirmed lumbar disk herniation patients: A comparative effectiveness prospective observational study of 2 age- and sex-matched cohorts treated with either high-velocity, low-amplitude spinal manipulative therapy or imaging-guided lumbar nerve root injections [J] . PetersonC.K., LeemannS., LechmannM., Journal of manipulative and physiological therapeutics: JMPT . 2013,第4期

机译：有症状的磁共振成像确认的腰椎间盘突出症患者：一项针对两组年龄和性别相匹配的队列的比较有效性的前瞻性观察性研究，这些队列均接受了高速，低幅脊椎手法治疗或影像引导的腰神经根注射治疗
3. Recurrence of Pain After Usual Nonoperative Care for Symptomatic Lumbar Disk Herniation: Analysis of Data From the Spine Patient Outcomes Research Trial [J] . Suri Pradeep, Pearson Adam M., Scherer Emily A., PM & R: the journal of injury, function, and rehabilitation . 2016,第5期

机译：症状性腰椎间盘突出症通常非手术治疗后疼痛的复发：脊柱患者结果研究试验的数据分析
4. Establishing a baseline for gait pattern that can be linked to lumbar disk herniation and recurrent lumbar disk herniation [C] . Sinziana Anca Moldoveanu, F. Munteanu, Anca Mihaela Lazar, IEEE International Conference on E-Health and Bioengineering . 2015

机译：建立可与腰椎间盘突出症和复发性腰椎间盘突出症相关的步态模式基线
5. The Utility of The Appendicitis Likelihood Model in Predicting Appendicitis in Adult and Pediatric Patients with Abdominal Pain Suspicious for Appendicitis and Pediatric Appendicitis: An Overview and Systematic Review of the Relative Utility of Pediatric [D] . Melville, Laura Diane. 2020

机译：阑尾炎似然模型在预测成人和儿科患者阑尾炎患者胃癌和儿科阑尾炎中的概念：概述及系统审查儿科的相对效用
6. Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients [O] . Siobán B. Keel, Angela Scott, Marilyn Sanchez-Bonilla, 2016

机译：小儿和年轻成人患者骨髓增生异常综合征和再生障碍性贫血的遗传特征
7. Relationship of Modic Changes, Disk Herniation Morphology, and Axial Location to Outcomes in Symptomatic Cervical Disk Herniation Patients Treated With High-Velocity, Low-Amplitude Spinal Manipulation: A Prospective Study [O] . Michel Kressig, Cynthia K. Peterson, Kyle McChurch, 2016

机译：症状宫颈椎间盘突症患者症状变化，磁盘疝气形态和轴向地点与高速，低幅度脊髓治疗患者的关系

Genetic Predisposition to Symptomatic Lumbar Disk Herniation in Pediatric and Young Adult Patients

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