Synthesis, characterization, theoretical studies and biological activity of coordination compounds with essential metals containing N4-donor ligand 2,9-di(ethylaminomethyl)-1,10-phenanthroline

摘要

Graphical abstractThis work present the synthesis and characterization of essential metals coordination compounds with ligand N4-donor 2,9-di(ethylaminomethyl)-1,10-phenanthroline. Complexes with diverse geometry and coordination number were obtained. Cyclic voltammetry studies showed different redox behavior for the compounds. Ligand amoebicide activity is increased by the metal. The moderate antitumor and amoebicide activity is linked to redox behavior this suggest an imbalance redox cell damage action mechanism.Display OmittedHighlights?The essential metals complexes with a N4-donor ligand derivative of Necouproine were synthetized and characterized.?The pH conditions and the rigidity of the ligand L impose the denticity either three or four coordinated.?The redox potencial values found for these complexes are a direct consequence of the π-acceptor nature of the ligand.?The antitumor and amoebicidal activity