Drugs for MRSA skin and soft-tissue infections

摘要

Methicillin-resistant Staphylococcus aureus (MRSA), which was traditionally a nosocomially-acquired organism but now frequently occurs in the absence of health care exposure, is the predominant cause of suppurative skin and soft-tissue infections in many parts of the US. Community-associated MRSA usually causes furunculosis, purulent cellulitis, and abscesses, but necro-tizing fasciitis, necrotizing pneumonia, and sepsis can also occur. Community-associated MRSA strains have been susceptible in vitro to vancomycin, daptomycin, and linezolid, and usually to clindamycin, trimethoprim/sulfamethoxazole (TMP/SMX), and tetracyclines. Nosocomial strains of MRSA are often resistant to clindamycin, tetracyclines, and TMP/SMX. Resistance to fluoro-quinolones is common and is increasing in both nosocomial and community settings.