Remote preconditioning and all-cause mortality

摘要

During the past three decades, experimental cardiology studies have shown that ischaemic conditioning interventions can lessen the risk of fatal reperfusion injury and reduce infarct size. Murry and colleagues1 noted that repeated brief episodes of myocardial ischaemia induced before a sustained ischaemic insult preconditioned the heart. Zhao and colleagues2 reported that a similar intervention applied immediately after (but not before) sustained ischaemic insult could postcondition the heart. Przyklenk and colleagues3 found that the application of short cycles of non-fatal ischaemia at a remote site (eg, the arm) before, during, or immediately after sustained occlusion of a coronary artery improved resistance to reperfusion injury to the heart compared with unconditioned hearts.