These authors conclude that a PSA cutoff of 1.5 ng/ml or greater can be used for risk stratification in men 50 years or younger, a group that may benefit from more frequent PSA testing. 1) This study suffers from verification bias. The biopsy rate in PSA subgroups was not known and is likely to differ. 2) Of the men 4% were diagnosed with prostate cancer (96% were not) at a mean of 1.4 years with a total followup of up to 9 years. In a clinical setting these values are 2.3% and 17 years, respectively.
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机译：这些作者得出的结论是，对于年龄在50岁以下的男性，可以使用1.5 ng / ml或更高的PSA临界值进行风险分层，该人群可能会从更频繁的PSA测试中受益。 1）该研究存在验证偏差。 PSA亚组的活检率尚不清楚，可能会有所不同。 2）在男性中，有4％的人平均1.4年被诊断出患有前列腺癌（96％的人没有），总随访期长达9年。在临床环境中，这些值分别为2.3％和17年。
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