One-pot oxidative carbon-carbon bond formation of 3-benzylic and 3-allylic indoles with carbon nucleophiles

摘要

Indolenines were generated at -78 degrees C from 3-benzylic or 3-allylic indoles by dehydrogenation with N-tert-butylbenzenesulfinimidoyl chloride, and a carbon-carbon bond was formed at -78 degrees C in a one-pot manner by treating these indolenines with various carbon nucleophiles such as active methylene compounds or organocuprates. (c) 2008 Elsevier Ltd. All rights reserved.