Marine derived natural products for osteoporosis

摘要

Bone homeostasis is maintained through a balance between osteoblastic bone formation and osteoclastic bone resorption. Aging induces bone loss due to decreased osteoblastic bone formation and increased osteoclastic bone resorption. Osteoporosis with its accompanying decrease in bone mass is widely recognized as a major public health problem. It is undoubted that pharmacological and nutritional factors are involved in the prevention of age-related bone loss. In the search for the appropriate treatment of osteoporosis, there is an interesting area of marine organisms and phytopharmacology. Extracts of marine algae and other marine derived compounds have a favorable effect on bone metabolism. This review discusses the current pharmacological therapies for osteoporosis and bioactive natural products from marine for the anti-osteoporotic research.