Clinical Manifestation, Distribution and Resistance of Pathogen Causing Bacteremias Following Solid Organ Transplantation: A Clinical Analysis of 149 PatientsAU Liu, Jia Shao, Mingjie Wan, Qiquan (13548685542@163.com) Ye, Qifa Zhou, Jiandang

摘要

Investigate the clinical manifestations and determine the distribution and characteristics of drug susceptibility of pathogen causing bacteremias, and provide evidence for clinical anti-infection treatments after solid organ transplantation. One hundred ninety eight episodes of bacteremias occurred in 149 patients-between January 2003 and February 2014. Retrospective analysis of the pathogens and their drug susceptibility characteristics was carried out using a BD microbiological assay system. We also collected clinical and laboratory data of the effected patients. The gram negative bacteria accounted for 59.1% of all pathogens (117/198). The most common gram negative bacillus was Escherichia coil, while for gram positive bacteria, the main bacillus was S. aureus. The gram negative bacteria were relatively sensitive to aminoglycosides and carbapenem, while the gram positive bacteria were sensitive to glycopeptides and oxazolidone. The clinical manifestations of bacteremias included high body temperatures, onset shortly after solid organ transplantation, as well as a high mortality rate. Though gram positive bacteria played an important role, most of the bacteremias were caused by gram negative bacteria. The rate of antibiotic-resistant cases was very high for both the gram negative and positive bacteria.C1 Wan, Qiquan; Cent S Univ, Affiliated Hosp 3, Dept Transplant Surg, Changsha 410013, Hunan, Peoples R ChinaSC Surgery; Infectious Diseases; Health Care Sciences & Services; General & Internal Medicine