Synthesis of Ethyl Isoxazole-3-Carboxylates Using an Ionic Liquid as a Soluble Support

摘要

A regioselective 1,3-dipolar cycloadditions of ionic liquid-supported vinyl ethers, derived from ionic liquid-supported α-phenylselenomethyl ether, with ethyl cyanoformate N-oxide gave supported isoxazoline derivatives, which were then cleaved from the ionic liquid support under mild acidic conditions to afford ethyl isoxazole-3-carboxylates. This new synthetic method is simple and efficient and the products are obtained in good yields.