Synthesis and In Vitro Antimicrobial Activity of 1,3,4-Oxadiazole-2-thiol and its Analogs

摘要

The present communication deals with the synthesis of 1,3,4-oxadiazole-2-thiol derivatives containing cyclic secondary amines such as morpholine, N-methyl piperizine, and piperizine. The structural elucidation is based on the spectral data (IR, H-1 NMR, and C-13 NMR) .The newly synthesized compounds were then tested for their antimicrobial activity against a representative panel of micro-organisms such as Bacillus subtilis, Escherichia coli and Candida albicans by using ciprofloxacin and fluconazole as reference drugs for bacteria and fungi, respectively. These synthesized compounds showed moderate to potential antibacterial and antifungal activity in the range of 6-50M against the selected bacteria and 12-50M against the most common fungi, respectively.