(Chemical Equation Presented) 1-Acylamino-2,5-dimethylpyrroles were prepared in the exploration of heterocyclic structures useful for their antitubercular activity. The pyrroles were conveniently formed from the reaction of aromatic acid hydrazides with hexane-2,5-dione in water or ethanol, without resorting to acid catalysis. In each case, the procedure provided a single pyrrole in pure form, and the product was identified without difficulty on the basis of highly characteristic spectrometric features. Some members of this class have significant activities against drug-resistant tuberculosis in vitro and offer substantial protection in a rigorous mouse model of the disease.
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