Synthesis, complexation, and biological activity studies of 4-aminomethyl-7,8-dihydroxy coumarines and their crown ether derivatives

摘要

(Chemical Equation Presented) The article focuses synthesis of novel 4-aminomethyl-7,8-dihydroxy coumarins and their crown ether derivatives. The purified novel coumarins and their crown ether derivatives were identified by ~1H NMR, ~(13)C NMR, mass spectrometry and elemental analysis. The 1:1 binding constants of Ca~(2+), Mg~(2+), Fe~(2+), Zn~(2+), Ni~(2+), Cd~(2+), Co~(2+), and Mn ~(2+) ions at 25°C ± 0.1 with the 4-aminomethyl-7,8-dihydroxy coumarins and their crown ether derivatives estimated using extraction procedure with Inductively Coupled Plasma-Atomic Emission Spectroscopy in dichloromethane/water membrane systems. Synthesized compounds were investigated for complexation and biological activity properties. Best results in biological activity studies were observed for antioxidant activity.