The first synthesis of 3-hydroxy-2-(polyfluoroalkyl)chromones and their ammonium salts. 3-Hydroxychromone in the Mannich reaction

摘要

(Chemical Equation Presented) 3-Hydroxy-2-(polyfluoroalkyl)chromones were obtained in good yields via the nitrozation reaction of 2-(polyfluoroalkyl) chroman-4-ones with isopropyl nitrite in the presence of hydrochloric acid. Treatment of 3-acetoxy-2-(trifluoromethyl)chromone with primary amines and hydrazine gave the corresponding ammonium salts. Reaction of 3-hydroxychromone, prepared by this method, with formaldehyde and α-aminoacids has been studied.