Synthesis and NMR analysis of spiranic heterocycles from carbohydrate derivatives

摘要

We report the synthesis of some furanose and pyranose acylhydrazones and their heterocyclization products. The new compounds were characterized physically and spectroscopically and the syn-anti and (R)-(S) configuration was determined by NOESY experiments. We discuss the influence of the nucleophile, the temperature and the precursor structure on the heterocyclization products.