INTRAMOLECULAR CYCLIZATION OF AMIDO ACIDS INTO PYRROLIDINOTHIENO (OR [1]BENZOTHIENO)[3]AZEPINEDIONES

摘要

The synthesis of pyrrolidino[2,1-b]thieno[3,2(2,3)-f][3]azepinediones 7a,b and pyrrolidino[2,1-b][1]benzothieno[3,2(2,3)-f][3]azepinediones 7c,d are described starting from thiophenes or [I]benzothiophenes acetic acids. Their selective reduction using triethylsilane led to the corresponding azepinones 17a-d. [References: 14]