Synthesis and Antibacterial Screening of New 4-((5-(Difluoromethoxy)-1H-benzo[d]imidazol-2-ylthio)methyl)-tetrazolo[1,5-a]quinoline Derivatives

摘要

A method for the synthesis of previously unknown heterocyclic systems 4-((5-(difluoromethoxy)-1Hbenzo[ d]imidazol-2-ylthio)methyl)tetrazolo[1,5-a]quinolines derivatives 6 has been developed based on various substitutes 2-chloroquinoline-3-carbaldehydes 1 via the consecutive steps of conversion into tetrazolo[ 1,5-a]quinoline-4-carbaldehyde 2 on treatment with sodium azide which upon reduction to the corresponding alcohol derivatives 3, conversion to chlorides 4 with thionyl chloride followed by the coupling with 5-(difluoromethoxy)-1H-benzo[d]imidazole-2-thiol 5. The synthesized titled compounds (6a–e) were screened for the antibacterial activity against gram positive and gram negative bacteria.