Stereoselective synthesis of new dihydropyrimidinone Glycoconjugates

摘要

Stereoselective synthesis of dihydropyrimidinone glycoconjugates in high yields, from different sugar aldehydes, by a three-component coupling (Biginelli) reaction is reported. In this new method, HCl generated 'in situ' from 2,4,6-trichloro[1,3,5]triazine (TCT; 10 mol%), was used under mild and solvent free reaction conditions.