Synthesis of new heterocondensed pteridines

摘要

Reaction of 2-aminopyrazine 1 with isothiocyanate, isocyanate or dithioketal reagent furnishede pteridines 3,4 in good yield. Thioxo compound 3a was chlorinate, methylated and subsequently displaced by amines. A simple one-step synthesis of heterocondensed pteridines 8-13 by reaction of 2-aminopyrazine with various imino thioacetals was described 8-13.