Molecular Imaging of Late Somatostatin Receptor-Positive Metastases of Renal Cell Carcinoma in the Pancreas by ~68Ga DOTATOC PET/CT: A Rare Differential Diagnosis to Multiple Primary Pancreatic Neuroendocrine Tumors

摘要

~68Ga somatostatin receptor PET/CT, currently the most sensitive imaging modality for well-differentiated neuroendocrine tumors, is based on the molecular imaging of somatostatin receptors (SSTRs) that are expressed in different tumor entities such as neuroendocrine neoplasms, lymphomas, meningi-omas, or renal cell cancer (RCC). Most neuroendocrine neoplasms show a high expression of SSTR subtypes 2A and 5, whereas the overexpression of SSTR2A in RCC is mainly seen in peritumoral vessels. Here we report a case with strongly SSTR-positive pancreatic lesions detected by ~68Ga DOTATOC PET/CT, which histologically turned out to be ultralate metastases of a RCC.