Determination of nifedipine using nanostructured electrochemical sensor based on simple synthesis ofAgnanoparticles atthe surface of glassy carbon electrode:Application tothe analysis ofsome real samples

摘要

For the firsttime,the catalytic activity ofnifedipine (NID)was studied atthe surface ofamodifiedelectrode which prepared by immobilization ofAgnanoparticles (AgNPs)atthe surface ofglassy carbon electrode. Agnanoparticles with diameters between 40and 70nmwere prepared byelectrochemical method using calix[4]arene as atemplate.Prepara tion ofthis electrode was simple and modifiedelectrode showed an excellent character for electrocatalytic reduction ofnifedipine.The scanning electron micros-copy (SEM) images ofthe modifiedelectrode were studied.Using differential pulse voltammetry (DPV), under the selected conditions,the cathodic peak currents increased linearly inthe NID concentration range of 0.8–60.0 μM and the detection limit for NID was found tobe0.72 μM. The NID contents ofcommercial samples of pharmaceuticals and human urine samples were successfully determined using standard addition method bythe modifiedelectrode.The studies onNID recovery from these samples gave values of 98–103%.