A 3,4-epoxypiperidine structure as a novel and simple DNA-cleavage unit.

Miyashita K; Park M; Adachi S; Seki S; Obika S; Imanishi T

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A 3,4-epoxypiperidine structure as a novel and simple DNA-cleavage unit.

机译：3,4-环氧哌啶结构是一种新颖而简单的DNA切割单元。

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摘要

Based on the 4-hydroxy-1-azabicyclo[3.1.0]hexane structure of azinomycin, a 3,4-epoxypiperidine structure was designed as a novel and simple alkylating molecular unit, and some 3,4-epoxypiperidine derivatives were found to show DNA-cleavage activity, the structural requirements for which were revealed.

机译：基于阿奇霉素的4-羟基-1-氮杂双环[3.1.0]己烷结构，设计了一个3,4-环氧哌啶结构作为一种新型的简单烷基化分子单元，发现一些3,4-环氧哌啶衍生物显示出DNA切割活性，揭示了其结构要求。

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《Bioorganic and Medicinal Chemistry Letters》 |2002年第7期|共3页
作者
Miyashita K; Park M; Adachi S; Seki S; Obika S; Imanishi T;
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正文语种 eng
中图分类药学;生物化学;
关键词
Alkylating Agents; DNA; 烷化剂;

机译：Alkylating Agents;DNA;烷化剂;

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1. 一种新颖、简单的银微米线的湿化学制备方法 [J] . 翟爱霞, 蔡雄辉, 姜晓晔, 中国有色金属学报（英文版） . 2012,第004期
2. A 3,4-epoxypiperidine structure as a novel and simple DNA-cleavage unit. [J] . Miyashita K, Park M, Adachi S, Bioorganic and Medicinal Chemistry Letters . 2002,第7期

机译：3,4-环氧哌啶结构是一种新颖而简单的DNA切割单元。
3. Highly efficient imide functionalized pyrrolo[3,4-c]-pyrrole-1,3-dione-based random copolymer containing thieno[3,4-c]pyrrole-4,6-dione and benzodithiophene for simple structured polymer solar cells [J] . Tamilavan Vellaiappillai, Roh Kyung Hwan, Agneeswari Rajalingam, Journal of Materials Chemistry, A. Materials for energy and sustainability . 2014,第47期

机译：高效的酰亚胺官能化吡咯并[3,4-c]-吡咯-1,3-二酮基无规共聚物，其中含有噻吩并[3,4-c]吡咯-4,6-二酮和苯并二噻吩，用于结构简单的聚合物太阳能电池
4. Reduced 3,4'-bipyrazoles from a simple pyrazole precursor: synthetic sequence, molecular structures and supramolecular assembly [J] . Viviana Cuartas, Braulio Insuasty, Justo Cobo, Acta crystallographica. Section C, Structural chemistry. . 2017,第10期

机译：来自简单吡唑前体的3,4'-双吡唑：合成序列，分子结构和超分子组件
5. Synthesis and crystal structure of a new 2D coordination polymer Ce(3,4-pydc)_2·H_2O(3,4-pydc ＝ pyridine-3,4-dicarboxylate) [C] . Fenghua Bai, Liping Zhang, Haiquan Su, International Conference on Advanced Engineering Materials and Technology . 2011

机译：新的2D配位聚合物Ce（3,4-PYDC）_2·H_2O（3,4-PYDC =吡啶-3,4-二羧酸盐）的合成和晶体结构
6. Electrochemical synthesis and characterization of polymers from bis(3,4-ethylenedioxythiophene)-thiophenes (BEDOT-Ts) and bis(3,4-ethylenedioxythiophene)-benzenes (BEDOT-Bs) as optoelectronic materials. [D] . Eaiprasertsak, Kalya. 2008

机译：双（3,4-乙撑二氧噻吩）-噻吩（BEDOT-Ts）和双（3,4-乙撑二氧噻吩）-苯（BEDOT-Bs）作为光电材料的聚合物的电化学合成和表征。
7. 4-Methyl-1,3-bis(3,4-methylenedioxybenzyl)-2-(3,4-methylenedioxyphenyl)imidazolidine [O] . Shu-Ping Yang, Li-Jun Han, Ai-Ping Wen, 2016

机译：4-甲基-1,3-双（3,4-甲基二烯二氧基苯甲酰基）-2-（3,4-甲基二烯二氧基苯甲酰基）咪唑烷
8. 新規アルキル化剤3,4-Epoxypiperidine誘導体の設計、合成とDNA切断活性に関する研究 [O] . 朴勉志, パクミョンジ 2017

机译：新型烷基化剂3,4-环氧哌啶衍生物的设计，合成及DNA切割活性的研究
9. Acid-Catalysed Cleavage of A 1,3-Photoadduct of Benzene and CIS-3,4-Dichlorocyclobutene: X-Ray Structure of 3,4-Dichlorotricyclo (4,3,1, 0(2,5) Dec-8-en-10-yl P-Nitrobenzoate. [R] . Subrahmanyam, G., inivasan, R., La Placa, S. J., 1974

机译：苯和CIs-3,4- Dichlorocyclobutene的1,3- photoadduct的酸催化裂解：3,4-Dichlorotricyclo（4,3,1，的X射线结构0（2.5）癸-8-烯-10-基p-硝基苯甲酸甲酯。

A 3,4-epoxypiperidine structure as a novel and simple DNA-cleavage unit.

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