Novel transcribed sequences represented in the complex genomic region 5q13

摘要

YACs from llic complex repetitive human genomic region 5ql3, spanning the spinal muscular atrophy (SMA) locus, have been searched Tor transcribed sequences using the method of End Ligation Coincident; Sequence Cloning. Six transcripts (PT1-6) have been identified, three of which (PT4, PT5 and PT6) are novel. Five of these elements hybridise to multiple loci in 5ql3, but PT5 is single copy and maps very close to markers that show linkage disequilibrium with SMA.