Synthesis and Some Reactions of 4-Benzoyl-5-Phenyl-l-(2,4,6-Trichloro Phenyl)-lH-Pyrazole-3-Carboxylic Acid

摘要

Furandione 1 was reacted with 2,4,6-trichlorophenylhydrazine to give the lH-pyrazole-3-carboxylic acid 2 together with a new pyridazinone derivative 3.Then 2 was converted into the corresponding ester 5 or amide 6 derivatives,respectively,via reactions of its acid chloride 4 with various alcohols or N-nucleophiles.Nitrile derivative 7 was obtained by dehydration of 6a in a mixture of SOCl_2 and DMF.Condensation reactions of 2 with some hydrazines led to the formation of pyrazolo [3,4-d] pyridazinone 8 derivatives.