5 Retina

摘要

Objective.-To determine if CFH and LOC38771S/ARMS2 genotypes influence treatment response to AREDS-type nutritional supplementation with antioxidants and zinc. Design.-Retrospective analysis of participants in a randomized, controlled clinical trial, the Age-Related Eye Disease Study (AREDS). Participants and/or Controls.-Eight hundred seventy-six AREDS study participants who were considered at high risk for developing advanced age-related macular degeneration (AMD). Methods.-Using DNA extracted from venous blood of 876 white participants in AREDS categories 3 and 4, that is, those considered to be at high risk for progression to advanced AMD, the authors genotyped for the single nucleotide polymorphisms in the CFH (Y402H, rsl061170) and LOC387715/ARMS2 (A69S, rsl0490924) genes. The authors performed adjusted unconditional logistic regression analysis and assessed interactions of these genotypes to determine the relationship between CFH and LOC387715/ARMS2 genotype and treatment with antioxidants plus zinc.