Evaluation of IL-2, IL-10, IL-17 and IP-10 as potent discriminative markers for active tuberculosis among pulmonary tuberculosis suspects

摘要

Introduction: Although interferon gamma release assays (IGRAs) are useful for specifically detecting Mycobacterium tuberculosis, they are limited by their inability to differentiate between active tuberculosis (active TB), latent tuberculosis infection (LTBI), and patients with prior TB infection. The purpose of this study was to rapidly and accurately identify active TB patients among patients with suspected respiratory TB by combining interferon-gamma (IFN-gamma) with additional cytokines.