Lack of species-specific difference in pulmonary function when using mouse versus human plasma in a mouse model of hemorrhagic shock

摘要

BACKGROUND: Clinical studies have demonstrated that the early and empiric use of plasma improves survival after hemorrhagic shock. We have demonstrated in rodent models of hemorrhagic shock that resuscitation with plasma is protective to the lungs compared with lactated Ringer's solution. As our long-term objective is to determine themolecular mechanisms thatmodulate plasma's protective effects in injured bleeding patients, we have used human plasma in a mouse model of hemorrhagic shock. The goal of the current experiments is to determine if there are significant adverse effects on lung injurywhen using human versus mouse plasma in an establishedmurinemodel of hemorrhagic shock and laparotomy.