Synthesis of Cyclopropanes via Organoiron Methodology:Preparation of rac-Dysibetaine CPa

摘要

The cyclopropane containing betaine,rac-dysibetaine CPa,was prepared from(1-methoxycarbonylpentadienyl)-Fe-(CO)2PPh_3~+by nucleophilic addition of nitromethane anion followed by oxidatively induced reductive elimination.Examination of the common South Pacific sponge Dysidea herbacea has led to the isolation of a wide variety of secondary metabolites,including the water-soluable amino acids dysi-herbaine(1)and neodysiherbaine-A(2)which are agonists for mammalian glutamate receptors(Figure 1).