Comment on 'Effect of conjugated estrogen versus conjugated estrogen associated with medroxyprogesterone acetate in postmenopausal women on internal carotid artery pulsatility index: A randomized pilot study'

摘要

We read the article by Maria C.Wender and colleagues1about whether estrogen (CEE) combined with syntheticprogestin (MPA) treatment or not would influencethe pulsatility index (PI) reduce effect by hormonereplacement therapy with interest. Hormone replacetherapy is a common treatment for postmenopausalwomen, and progesterone is also necessary in additionto estrogen for women with intact uteruses to reducethe risk of endometrial hyperplasia.2 However, progesteronehas been described as having adverse effects oncognitive performance or as reversing the possiblebeneficial effect of estrogen,3 so the effortto find little side-effect synthetic progestin is veryuseful.