Randomized Clinical Trial of a Sustained-Exposure Ciprofloxacin for Intratympanic Injection During Tympanostomy Tube Surgery

Mair Eric A.; Moss Jonathan R.; Dohar Joseph E.; Antonelli Patrick J.; Bear Moraye; LeBel Carl

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Randomized Clinical Trial of a Sustained-Exposure Ciprofloxacin for Intratympanic Injection During Tympanostomy Tube Surgery

机译：持续暴露环丙沙星用于鼓室造口术中鼓膜内注射的随机临床试验。

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摘要

Objective: This exploratory clinical trial evaluated the safety and clinical activity of a novel, sustained-exposure formulation of ciprofloxacin microparticulates in poloxamer (OTO-201) administered during tympanostomy tube placement in children.

机译：目的：该探索性临床试验评估了在儿童鼓膜置管放置期间施用的新型持续暴露的环丙沙星微粒在泊洛沙姆（OTO-201）中的安全性和临床活性。

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《The Annals of otology, rhinology, and laryngology》 |2016年第2期|共10页
作者
Mair Eric A.; Moss Jonathan R.; Dohar Joseph E.; Antonelli Patrick J.; Bear Moraye; LeBel Carl;
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正文语种 eng
中图分类耳鼻咽喉科学;
关键词
middle ear effusion; otitis media; OTO-201; ciprofloxacin; sustained exposure; tympanostomy tube; culture; otorrhea;

机译：中耳积液;中耳炎;OTO-201;环丙沙星;持续暴露;鼓膜造口术;培养;耳漏;

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1. Randomized Clinical Trial of a Sustained-Exposure Ciprofloxacin for Intratympanic Injection During Tympanostomy Tube Surgery [J] . Mair Eric A., Moss Jonathan R., Dohar Joseph E., The Annals of otology, rhinology, and laryngology . 2016,第2期

机译：持续暴露环丙沙星用于鼓室造口术中鼓膜内注射的随机临床试验。
2. Efficacy and Safety of Ciprofloxacin Plus Fluocinolone in Otitis Media With Tympanostomy Tubes in Pediatric Patients A Randomized Clinical Trial [J] . Spektor Zorik, Pumarola Felix, Ismail Khaleed, JAMA otolaryngology-- head & neck surgery . 2017,第4期

机译：CiProfloxacin Pluocinolone在儿科患者中具有鼓膜膜膜中脑膜炎培养基中的疗效和安全性A随机临床试验
3. Topical ciprofloxacin is superior to topical saline and systemic antibiotics in the treatment of tympanostomy tube otorrhea in children: the results of a randomized clinical trial. [J] . Heslop A, Lildholdt T, Gammelgaard N, The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. . 2010,第12期

机译：环丙沙星局部治疗儿童鼓室造口术中的耳漏优于局部生理盐水和全身性抗生素：一项随机临床试验的结果。
4. Monocyte chemotactic protein-1 and E-selectin inflammatory patterns in coronary artery bypass graft surgery with the miniaturized extracorporeal circulation: a randomized clinical trial [C] . Mariani S., Formica F., Broccolo F., International Congress on Coronary Artery Disease. . 2013

机译：单核细胞趋化蛋白-1和冠状动脉旁路移植手术中的e-Selectin炎性模式，具有小型化体外循环：随机临床试验
5. Randomized clinical trials evaluating therapeutic influences of ornamental indoor plants in hospital rooms on health outcomes of patients recovering from surgery [D] . Park, Seong-Hyun 2006

机译：评估医院室内观赏室内植物对手术康复患者健康结局的治疗影响的随机临床试验
6. Randomized Clinical Trial of a Sustained-Exposure Ciprofloxacin for Intratympanic Injection During Tympanostomy Tube Surgery [O] . Eric A. Mair, Jonathan R. Moss, Joseph E. Dohar, -1

机译：持续暴露环丙沙星用于鼓室造口术中鼓膜内注射的随机临床试验。
7. Efectividad de la ciprofloxacina tópica en la prevención de la otorrea postoperatoria temprana luego de miringocentesis más tubos de ventilación en pacientes menores deud18 años: ensayo clínico aleatorizado triple ciego controlado con placebo / Effectiveness of the topic ciprofloxacin in the prevention of earlyudpostoperative otorrhea after tympanostomy tube placement in under eighteen patients: triple-blind placebo-controlled, randomized clinical trial [O] . Duarte Silva Juan Pablo 2012

机译：外用环丙沙星预防术后早期耳廓炎的有效性，以及小于您的患者的气管插管加通气管18年：安慰剂对照随机三盲临床试验/环丙沙星预防早期治疗的有效性18岁以下患者鼓室置管后放置术后耳漏：三盲安慰剂对照，随机临床试验

Randomized Clinical Trial of a Sustained-Exposure Ciprofloxacin for Intratympanic Injection During Tympanostomy Tube Surgery

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