Synthesis of #delta#-Amino Acids with an Ether Linkage in the Main Chain and Nucleobases on the Side Chain as Monomer Units for Oxy-Peptide Nucleic Acids

摘要

Syntheses of four N-Fmoc #delta#-amino acids withan ether linkage inthe main chain and four different nucleobases on the side chain, Fmoc-NH-C~*H(CH_2-CH_2B)-CH_2-O-CH_2-COOH(B=thymine, uracil,N~4-benzoylcytosine,and N~2-isobutyrylguanine) are described. The #delta#-amino acids were prepared through 8-12 step synthesis starting from L-homoserine and could be linked together to form novel peptide nucleic acids(oxy-PNAs=OPNAs).