Therapeutic modulation and reestablishment of the intestinal Microbiota with fecal Microbiota transplantation resolves sepsis and diarrhea in a patient

摘要

To the Editor: We read with great interest the article regarding the therapeutic value of fecal microbiota transplantation (FMT) in ulcerative colitis (1). FMT has emerged as an accepted treatment for recurrent Clostridium difficile-associated diarrhea (2-4). It represents a therapeutic protocol that allows reconstitution of a normal composition of gut microbial community. Dysbiosis of gut microbiota is probably relevant for the etiology of sepsis, raising an interesting possibility of microbiota-targeted therapy in these cases. Here, we describe the case of a sepsis patient with severe diarrhea who received FMT and report findings.