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Reply by the Authors

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We acknowledge the comments of our readers and take this opportunity to clarify some points regarding our original paper.We agree that all patients should ideally have both a pre- and postoperative DMSA scan to document scarring. However, in our population, only 15% of patients showed renal scars on preoperative imaging after recur-rent pyelonephritis, thus making the odds of new ones extremely low, especially without other infection. Furthermore, we assert that renal scarring after pyelonephritis is a rare event in adults as compared to the pediatric population. Early treatment was shown to be effective in preserving nephron integrity. In our study, we did not consider observation to be an alternative option because of the recurring pattern of pyelonephritis; most patients had already failed conservative management, ie, observation, antibiotic prophylaxis, or treatment of dysfunctional voiding. We argue that the control of infective events alone had a great impact on the patients who needed admission. Loss of productivity with major impact on daily activities for several days was documented for a large number of patients.
机译:我们感谢读者的评论,并借此机会澄清与原始论文有关的一些观点。我们同意,所有患者均应在术前和术后进行DMSA扫描以记录瘢痕形成。但是,在我们的人群中,只有15%的患者在复发性肾盂肾炎手术前影像学上显示出肾脏瘢痕,因此,新患者的机率极低,尤其是没有其他感染的患者。此外,我们断言,与儿科人群相比,肾盂肾炎后肾瘢痕形成在成年人中是罕见的事件。早期治疗被证明在保持肾单位完整性方面是有效的。在我们的研究中,由于肾盂肾炎的复发模式,我们不认为观察是另一种选择。大多数患者的保守治疗均已失败,即观察,预防抗生素或治疗功能障碍性排尿失败。我们认为,仅控制感染事件会对需要入院的患者产生巨大影响。大量患者的生产力下降对几天的日常活动产生重大影响。

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