Highlights From The Literature

摘要

Question:Do Drosophilaand yeast share a common pathway to attract lipid-modified peptides? Background: To reproduce successfully, germ cells, which are the progenitors of gametes and formed at a site distant from the somatic part of the gonad, must migrate from one side of the epithelium to the other. In Drosophila, the migration of germ cells is regulated by the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). In fact, when HMGCR or enzymes in the HMGCR pathway are mutated, suchas the beta-subunit of type I geranygeranyl transferase (beta GGTI), germ cell migration is defective.