摘要：Surface mobility plays an important role in governing the physical stability of amorphous pharmaceutical solids.Griseofulvin, a poorly water-soluble antifungal drug, grows crystals much faster at the free surface than in the bulk.The phenomena of fast protruding crystal growth in the supercooled liquid of griseofulvin and fast crystal growth along the cracks in the griseofulvin glass are believed to be surface-facilitated crystallization.
摘要：Polymorphism has been an important issue in the chemical industry for over a century. The existence of different crystal structures of the various polymorphs of a substance often results in different physical and chemical properties. Griseofulvin (GSF) has been widely used in clinical for treatment of ringworm in animals and humans over 50 years.It also serves as a model system for studying the physicochemical properties of poorly water-soluble drugs. However, the polymorphism of GSF was recognized until recently.
