A multicenter phase II clinical study of oxaliplatin, folinic acid, and 5-fluorouracil combination chemotherapy as second-line treatment for advanced colorectal cancer: A Japanese experience

Yutaka Ogata; Shoji Tokunaga; Yasunori Emi; Eiji Oki; Hiroshi Saeki; Ken Shirabe; Hirofumi Hasegawa; Noriaki Sadanaga; Hironori Samura; Fumihiko Fujita; Takaho Tanaka; Masaki Kitazono; Manabu Yamamoto; Tatsuma Morikita; Masafumi Inomata; Yoshihiro Kakeji; Kazuo Shirouzu; Yoshihiko Maehara

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A multicenter phase II clinical study of oxaliplatin, folinic acid, and 5-fluorouracil combination chemotherapy as second-line treatment for advanced colorectal cancer: A Japanese experience

机译：奥沙利铂，亚叶酸和5-氟尿嘧啶联合化疗作为晚期结肠直肠癌的二线治疗的多中心II期临床研究：日本的经验

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This multicenter phase II study was designed to determine the efficacy and tolerability of oxaliplatin, levoforinate, and infusional 5-fluorouracil (FOLFOX4) as a second-line therapy for Japanese patients with unresectable advanced or metastatic colorectal cancer.

机译：这项多中心II期研究旨在确定奥沙利铂，左氧氟酸和5-氟尿嘧啶输注（FOLFOX4）作为日本不可切除的晚期或转移性结直肠癌患者的二线治疗的疗效和耐受性。

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来源
《Surgery Today》 |2011年第1期|p.84-90|共7页
作者
Yutaka Ogata; Shoji Tokunaga; Yasunori Emi; Eiji Oki; Hiroshi Saeki; Ken Shirabe; Hirofumi Hasegawa; Noriaki Sadanaga; Hironori Samura; Fumihiko Fujita; Takaho Tanaka; Masaki Kitazono; Manabu Yamamoto; Tatsuma Morikita; Masafumi Inomata; Yoshihiro Kakeji; Kazuo Shirouzu; Yoshihiko Maehara;
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作者单位

Department of Surgery, Kurume University School of Medicine, Kurume, Japan;

Department of Medical Informatics, Kyushu University Hospital, Fukuoka, Japan;

Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan;

Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan;

Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan;

Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan;

Department of Surgery, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, Japan;

Department of Surgery, Saiseikai Fukuoka General Hos;

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正文语种 eng
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关键词
FOLFOX4; Multicenter phase II clinical trial; Advanced colorectal cancer; Second-line chemotherapy;

机译：FOLFOX4;多中心II期临床试验;晚期结直肠癌;二线化疗;

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专利

1. A multicenter phase II clinical study of oxaliplatin, folinic acid, and 5-fluorouracil combination chemotherapy as second-line treatment for advanced colorectal cancer: a Japanese experience. [J] . Ogata Y, Tokunaga S, Emi Y, Surgery today . 2011,第1期

机译：奥沙利铂，亚叶酸和5-氟尿嘧啶联合化疗作为晚期大肠癌的二线治疗的多中心II期临床研究：日本的经验。
2. A multicenter phase II clinical study of oxaliplatin, folinic acid, and 5-fluorouracil combination chemotherapy as first-line treatment for advanced colorectal cancer: A Japanese experience [J] . Hideo Baba, Naoko Hayashi, Yasunori Emi, Surgery Today . 2011,第12期

机译：奥沙利铂，亚叶酸和5-氟尿嘧啶联合化疗作为晚期结直肠癌的一线治疗的多中心II期临床研究：日本的经验
3. A multicenter phase II clinical study of oxaliplatin, folinic acid, and 5-fluorouracil combination chemotherapy as first-line treatment for advanced colorectal cancer: a Japanese experience. [J] . Baba H, Hayashi N, Emi Y, Surgery today . 2011,第12期

机译：奥沙利铂，亚叶酸和5-氟尿嘧啶联合化疗作为晚期大肠癌的一线治疗的多中心II期临床研究：日本的经验。
4. Efficacy of combination chemotherapy with docetaxel and irinotecan as first- or second-line treatment for advanced gastric cancer [C] . K. Sugiyama, A. Ishikawa, T. Watanabe International Gastric Cancer Congress . 2009

机译：组合化疗与多西紫杉醇和伊替康的疗效，作为晚期胃癌的第一或二线治疗
5. Prospective Phase II Multicenter Registry of Ablation after Breast Lumpectomy Added to Extend (ABLATE) Intraoperative Margins in the Treatment of Breast Cancer [D] . Klimberg, V. Suzanne. 2017

机译：乳房肿块切除术后消融的前瞻性II期多中心消融术增加了扩大（ABLATE）术中切缘在治疗乳腺癌中的作用
6. Biweekly oxaliplatin raltitrexed 5-fluorouracil and folinic acid combination chemotherapy during preoperative radiation therapy for locally advanced rectal cancer: a phase I–II study [O] . A Avallone, P Delrio, C Guida, 2006

机译：局部晚期直肠癌术前放疗期间每两周一次奥沙利铂雷替曲沙5-氟尿嘧啶和亚叶酸联合化疗：I-II期研究
7. Oxaliplatin, Folinic Acid and 5-Fluorouracil (FOLFOX-4) Combination Chemotherapy as Second-line Treatment in Advanced Colorectal Cancer Patients with Irinotecan Failure: A Korean Single-center Experience [O] . Se Hoon Park, Ju Young Sung, Sang-hoon Han, 2005

机译：奥沙利铂，亚叶酸和5-氟尿嘧啶（FOLFOX-4）联合化疗作为晚期结直肠癌伊立替康失败患者的二线治疗：韩国单中心体验

A multicenter phase II clinical study of oxaliplatin, folinic acid, and 5-fluorouracil combination chemotherapy as second-line treatment for advanced colorectal cancer: A Japanese experience

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