Wearable Tape-Based Smart Biosensing Systems for Lactate and Glucose

摘要

The development of new bioelectronic platforms could provide exciting new opportunities for clinical analysis, environmental monitoring, and defense. Wearable adhesive tapes could adhere to skin to be in close contact with sweat that consists of many healthcare-related proteins, small molecules, and ions, and thus could function as unique platforms for the sensor construction. Here, we show for the first time the construction of wearable adhesive tape-based smart biosensing systems, and their determinations of lactate and glucose. The sensor is built by printing carbon graphite and Ag/AgCl inks on an adhesive tape to function as the working, reference, and counter electrodes, followed by the immobilization of lactate oxidase or glucose oxidase on the working electrode. The sensor shows a sensitive and broad detection range from micromolar to millimolar, and a quick measuring time of within 5 min for the determination of lactate or glucose. It is expected that these results could open up exciting new avenues for the development of novel wearable sensors, and toward advanced sweat-sensor applications.