Keeping Survivin Nimble at Centromeres in Mitosis

摘要

No one would expect an orchestra to perform Beethoven's ninth symphony without a conductor. It is therefore no surprise that when cells perform their most dramatic tour de force-division by mitosis-the process is carefully directed by a team of regulators. Like a conductor, these regulators activate key players in the mitotic program at precise times and locations within the cell. Some act globally. For example, activation of key cyclin-dependent kinases triggers the start of mitotic events throughout the cell, whereas activation of the ubiquitin-dependent proteolysis system by the anaphase-promoting complex/cyclosome similarly triggers the exit from mitosis.