A STEP into Darkness or Light?

John P. Moore; P. J. Klasse; Matthew J. Dolan; Sunil K. Ahuja

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A STEP into Darkness or Light?

机译：步入黑暗还是光明？

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The outcome of the efficacy trial of an adenovirus serotype 5 (Ad5) vector-based HIV-1 vaccine last November (STEP trial) was unexpected. Not only was the vaccine ineffective at lowering plasma viremia postinfection, but it may have increased the risk of

机译：去年11月基于腺病毒血清型5（Ad5）载体的HIV-1疫苗的功效试验（STEP试验）的结果出乎意料。该疫苗不仅不能有效降低感染后的血浆病毒血症，而且可能增加了感染的风险。

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来源
《Science》 |2008年第5877期|p.753-755|共3页
作者
John P. Moore; P. J. Klasse; Matthew J. Dolan; Sunil K. Ahuja;
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作者单位

Weill Medical College of Cornell University, New York, NY 10065, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Rate-limiting steps in the dark-to-light transition of Photosystem II - revealed by chlorophyll- a fluorescence induction [J] . Melinda Magyar, Gábor Sipka, László Kovács, Scientific reports. . 2018,第1期

机译：叶绿素II的黑暗到光转变的速率限制步骤 - 叶绿素 - 荧光诱导
2. Emerging from the darkness and stepping into the light: Implementing an understanding of the experience of nurse addiction into nursing education [J] . Karen Lee Burton Journal of Nursing Education and Practice . 2014,第4期

机译：从黑暗中出现并踩到光线：实施理解护士瘾的经验，进入护理教育
3. Changes of chlorophyll(ide) fluorescence yield induced by a short light pulse as a probe to monitor the early steps of etioplast phototransformation in dark-grown leaves [J] . Eullaffroy P., Franck F., Popovic R. Photochemistry and Photobiology: An International Journal . 1998,第6期

机译：短脉冲脉冲作为探针监测叶绿体光转化早期阶段叶绿素（ide）荧光产量的变化
4. SIMULATING THE PRODUCTION AND EFFECTS OF DARK CURRENTS IN MICE STEPS V AND VI [C] . C. Hunt, J. Pasternak, M. A. Uchida International Particle Accelerator Conference . 2014

机译：模拟小鼠步骤V和VI的暗电流的生产和影响
5. Using the dark to see: Dark matter and neutrinos enlighten the universe [D] . Laha, Ranjan 2014

机译：使用黑暗看：暗物质和中微子启动宇宙
6. Rate-limiting steps in the dark-to-light transition of Photosystem II - revealed by chlorophyll-a fluorescence induction [O] . Melinda Magyar, Gábor Sipka, László Kovács, -1

机译：叶绿素-a荧光诱导揭示光系统II从暗到光过渡的速率限制步骤
7. Figure 14: (A) Distribution of carbonyl (red) compared to the distribution of other compounds (cyan) in a 65 × 50 µm area of the sample. This area was measured in 0.1 µm steps. A layer of skin, identified by the yellow rectangle and predominantly composed of carbonyl, can be seen diagonally at the top-left corner of the image. The white arrow points towards the top of the skin. The red box represents the area detailed in (B). (B) Carbonyl (288.5 eV) map of the area within the red rectangle depicted in (A). The map covers an area of 20 × 20 µm of the sample in steps of 0.1 µm. The scale bar is 2 µm. Dark areas correspond to the presence of carbonyl (the data were collected with the detector in X-ray absorption mode). The yellow rectangle highlights a carbonyl layer which seems to be organized in smaller substructures, with three of them delineated by the white circles. (C) Elemental mapping of carbon (red), calcium (blue) and iron (green) of one of the substructures indicated by the white arrow in (B). [O] . -1

机译：图14：（a）与样品的65×50μm面积中的其他化合物（青色）的分布相比，羰基（红色）分布。该区域以0.1μm的步骤测量。由黄色矩形识别并主要由羰基构成的皮肤层可以在图像的左上角对角线地看到。白色箭头指向皮肤的顶部。红色框表示（b）中详述的区域。（b）（a）所示的红色矩形内区域内的区域的羰基（288.5 ev）图。该地图覆盖在0.1μm的步长的20×20μm的面积。秤条是2μm。暗区对应于羰基的存在（用X射线吸收模式用探测器收集数据）。黄矩形突出显示似乎在较小的子结构中组织的羰基层，其中三个被白色圆圈描绘。（c）由（b）中的白色箭头所示的一个子结构的碳（红色），钙（蓝色）和铁（绿色）的元素映射。

A STEP into Darkness or Light?

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